ID   NAH3_METJA              Reviewed;         388 AA.
AC   Q58671;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Probable Na(+)/H(+) antiporter 3;
DE   AltName: Full=MjNapA;
GN   OrderedLocusNames=MJ1275;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   SIMILARITY TO NA(+)/H(+) ANTIPORTERS.
RX   PubMed=12220668; DOI=10.1016/s0014-5793(02)03244-1;
RA   Hellmer J., Paetzold R., Zeilinger C.;
RT   "Identification of a pH regulated Na(+)/H(+) antiporter of Methanococcus
RT   jannaschii.";
RL   FEBS Lett. 527:245-249(2002).
CC   -!- FUNCTION: This is probably a Na(+)/H(+) antiporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB99281.1; -; Genomic_DNA.
DR   PIR; B64459; B64459.
DR   RefSeq; WP_010870788.1; NC_000909.1.
DR   AlphaFoldDB; Q58671; -.
DR   SMR; Q58671; -.
DR   STRING; 243232.MJ_1275; -.
DR   EnsemblBacteria; AAB99281; AAB99281; MJ_1275.
DR   GeneID; 1452173; -.
DR   KEGG; mja:MJ_1275; -.
DR   eggNOG; arCOG01953; Archaea.
DR   HOGENOM; CLU_005126_7_1_2; -.
DR   InParanoid; Q58671; -.
DR   OMA; EDKGDMQ; -.
DR   OrthoDB; 79669at2157; -.
DR   PhylomeDB; Q58671; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..388
FT                   /note="Probable Na(+)/H(+) antiporter 3"
FT                   /id="PRO_0000052404"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  42180 MW;  FF07E8CAEBA4F0CC CRC64;
     MESYYYVFFI ILSIIFIVPN LLKKFNIPAI TSIMIAGIII GPYGLNILQV DETLKILADF
     GAIMLMFLAG LEVDNETLKQ EFKNSLILSL FSLLIPGVGG YLIGQYLGLG FIGSLLYAVI
     FASHSVAIVY AILEELKMVK TRLGTIILSA TIIVDLFTLL LLSVVIKLGI GGENVGTFLL
     ETVLYIGVLL LAIPSLSKNI LGVFEKLHAQ RIHYVLFIIF IAIIVGEVIG IHPIVGAFIC
     GVAVSEALTK EEHDELLNKN LNAIGYGFFI PIFFLVLGME TNIRVIFNLS NLELLLITLI
     SAVALKFISG FIALRILGFD RIKNTIGGLL TVPKISASLV AASIGRELGL IGNEIFVTIV
     ALSVITATIT PIVVKHIFVA KCNKKAKN