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NAHB_PSEU8
ID   NAHB_PSEU8              Reviewed;         259 AA.
AC   P0A170; O33462; Q52459;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase;
DE            EC=1.3.1.29;
DE   AltName: Full=Cis-naphthalene dihydrodiol dehydrogenase;
DE   AltName: Full=Dibenzothiophene dihydrodiol dehydrogenase;
DE            EC=1.3.1.60;
GN   Name=doxE;
OS   Pseudomonas sp. (strain C18).
OG   Plasmid unnamed.
OC   Bacteria; Proteobacteria.
OX   NCBI_TaxID=69011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C18; PLASMID=unnamed;
RX   PubMed=8226631; DOI=10.1128/jb.175.21.6890-6901.1993;
RA   Denome S.A., Stanley D.C., Olson E.S., Young K.D.;
RT   "Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains:
RT   complete DNA sequence of an upper naphthalene catabolic pathway.";
RL   J. Bacteriol. 175:6890-6901(1993).
CC   -!- FUNCTION: Catalyzes the oxidation of naphthalene dihydrodiol into 1,2-
CC       dihydroxynaphthalene.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH
CC         + naphthalene-1,2-diol; Xref=Rhea:RHEA:11832, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17435, ChEBI:CHEBI:44343, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.3.1.29;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-
CC         dihydroxydibenzothiophene + H(+) + NADH; Xref=Rhea:RHEA:24188,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16941, ChEBI:CHEBI:17212,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.60;
CC   -!- PATHWAY: Aromatic compound metabolism; naphthalene degradation.
CC   -!- MISCELLANEOUS: Encoded on an unnamed 75 kb plasmid.
CC       {ECO:0000305|PubMed:8226631}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16128.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; M60405; AAA16128.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P0A170; -.
DR   SMR; P0A170; -.
DR   KEGG; ag:AAA16128; -.
DR   UniPathway; UPA00082; -.
DR   GO; GO:0018505; F:cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0018513; F:dibenzothiophene dihydrodiol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT   CHAIN           1..259
FT                   /note="1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase"
FT                   /id="PRO_0000054731"
FT   ACT_SITE        153
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         8..32
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   259 AA;  27528 MW;  B77E517D88789380 CRC64;
     MGNQQVVSIT GAGSGIGLEL VRSFKSAGYY VSALVRNEEQ EALLCKEFKD ALEIVVGDVR
     DHATNEKLIK QTIDRFGHLD CFIANAGIWD YMLSIEEPWE KISSSFDEIF DINVKSYFSG
     ISAALPELKK TNGSVVMTAS VSSHAVGGGG SCYIASKHAV LGMVKALAYE LAPEVRVNAV
     SPGGTVTSLC GPASAGFDKM HMKDMPGIDD MIKGLTPLGF AAKPEDVVAP YLLLASRKQG
     KFITGTVISI DGGMALGRK
 
 
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