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NAHF_PSEPU
ID   NAHF_PSEPU              Reviewed;         483 AA.
AC   P0A391; O34269; Q52460;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Salicylaldehyde dehydrogenase;
DE            EC=1.2.1.65;
GN   Name=nahF;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OG   Plasmid NPL1, and Plasmid NPL-41.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BS202; PLASMID=NPL1;
RA   Bezborodnikov S.G., Boronin A.M., Tiedje J.M.;
RT   "Nucleotide sequences of genes encoding an upper pathway of naphthalene
RT   metabolism of NPL1 plasmid from Pseudomonas putida strain BS202.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 221-483.
RC   STRAIN=BS202; PLASMID=NPL-41;
RA   Piruzian E.S., Serebryiskaya T.S., Lenets A.A., Goldenkova I.V.,
RA   Kobets N.S.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate;
CC         Xref=Rhea:RHEA:18537, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16008, ChEBI:CHEBI:30762, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.65;
CC   -!- PATHWAY: Aromatic compound metabolism; naphthalene degradation.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; AF010471; AAB62710.1; -; Genomic_DNA.
DR   EMBL; Y14173; CAA74578.1; -; Genomic_DNA.
DR   RefSeq; NP_863075.1; NC_004999.1.
DR   RefSeq; WP_011117403.1; NC_004999.1.
DR   AlphaFoldDB; P0A391; -.
DR   SMR; P0A391; -.
DR   BioCyc; MetaCyc:MON-12810; -.
DR   UniPathway; UPA00082; -.
DR   GO; GO:0018485; F:salicylaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT   CHAIN           1..483
FT                   /note="Salicylaldehyde dehydrogenase"
FT                   /id="PRO_0000056589"
FT   ACT_SITE        250
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        284
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         228..233
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        318
FT                   /note="V -> RL (in Ref. 2; CAA74578)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        365
FT                   /note="I -> M (in Ref. 2; CAA74578)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   483 AA;  51994 MW;  CD606BADD21DFACE CRC64;
     MKTKLFINNA WIDSSDQQTF ERIHPVSSDV VTESANATVT DAIKAAQAAE EAFKTWKAVG
     PSERRRLLLK VADVMESKTP KFIEVMAMEV GASALWAGFN VHASANVFRE AASLATQIQG
     ETIPTDKAET LSMTLRQPVG PILSIVPWNG TAVLAARAIA YPLVCGNTVV FKGSEFSPAT
     HALITQCVQE AGLPAGVLNY LNSSPDRSPE IADALISAKE IRRINFTGST RVGSIIAQKA
     AQHLKRCLLE LGGKSPLIVL DDADIDAAVK AAVFGSFLFQ GQICMSTERL IVDEKIADEF
     VAKFVEKTKR LSAGDPCVTG DCIIGPMVSP NSGERINGLF KDAIDKGAKV VCGGLAQGAL
     MPATILDHVK SDMRIYDEET FGPITVVIRC KGEAEAVRIA NDSVYGLSSG VFGRDINRAL
     RVGMSIEYGS VHINGSTVQN EAQAPYGGTK NTGYGRFDGR AVIDEFTEIK WLTIEPFEQQ
     YPF
 
 
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