ID   NAIF1_BOVIN             Reviewed;         327 AA.
AC   A7MBH3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Nuclear apoptosis-inducing factor 1;
GN   Name=NAIF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Placenta;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces apoptosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HARBI1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAIF1 family. {ECO:0000305}.
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DR   EMBL; BC151557; AAI51558.1; -; mRNA.
DR   RefSeq; NP_001094544.1; NM_001101074.2.
DR   AlphaFoldDB; A7MBH3; -.
DR   STRING; 9913.ENSBTAP00000016123; -.
DR   PaxDb; A7MBH3; -.
DR   Ensembl; ENSBTAT00000016123; ENSBTAP00000016123; ENSBTAG00000012156.
DR   GeneID; 510689; -.
DR   KEGG; bta:510689; -.
DR   CTD; 203245; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012156; -.
DR   VGNC; VGNC:31872; NAIF1.
DR   eggNOG; ENOG502QW9U; Eukaryota.
DR   GeneTree; ENSGT00450000040324; -.
DR   HOGENOM; CLU_078961_0_0_1; -.
DR   InParanoid; A7MBH3; -.
DR   OMA; EMIAQHA; -.
DR   OrthoDB; 1169567at2759; -.
DR   TreeFam; TF332812; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000012156; Expressed in semen and 104 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IEA:Ensembl.
DR   InterPro; IPR028002; Myb_DNA-bind_5.
DR   InterPro; IPR026753; NAIF1.
DR   PANTHER; PTHR23098; PTHR23098; 1.
DR   Pfam; PF13873; Myb_DNA-bind_5; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Nucleus; Reference proteome.
FT   CHAIN           1..327
FT                   /note="Nuclear apoptosis-inducing factor 1"
FT                   /id="PRO_0000342205"
FT   REGION          1..70
FT                   /note="Required for nuclear localization and apoptosis-
FT                   inducing activity"
FT                   /evidence="ECO:0000250"
FT   REGION          88..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  35194 MW;  E876D72EF24D28F8 CRC64;
     MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT
     CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPTE EDGAGGPGTG GGSGAGGPAV
     APVLLTPMQQ RICNLLGEAT IISLPSTAEI HPVALGPTAT AAAATVTLTQ IPTETTYHTL
     EEGVVEYCTA EAPPPLPAEA PVEMMAQHAD TSVKPQALKS RIALNSAKLI QEQRVTNLHV
     KEIAQHLEQQ NDLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQVLR PMIKDFRRYL
     QSNMPNPATA SEPGQVAQNG QPDSIIQ