ID   NAIF1_CHICK             Reviewed;         330 AA.
AC   Q5ZI27;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Nuclear apoptosis-inducing factor 1;
GN   Name=NAIF1; ORFNames=RCJMB04_31b24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Induces apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAIF1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720957; CAG32616.1; -; mRNA.
DR   AlphaFoldDB; Q5ZI27; -.
DR   STRING; 9031.ENSGALP00000041923; -.
DR   PaxDb; Q5ZI27; -.
DR   VEuPathDB; HostDB:geneid_417229; -.
DR   eggNOG; ENOG502QW9U; Eukaryota.
DR   InParanoid; Q5ZI27; -.
DR   PhylomeDB; Q5ZI27; -.
DR   PRO; PR:Q5ZI27; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000801; C:central element; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IBA:GO_Central.
DR   GO; GO:0010705; P:meiotic DNA double-strand break processing involved in reciprocal meiotic recombination; IBA:GO_Central.
DR   GO; GO:0048477; P:oogenesis; IBA:GO_Central.
DR   GO; GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR   InterPro; IPR028002; Myb_DNA-bind_5.
DR   InterPro; IPR026753; NAIF1.
DR   PANTHER; PTHR23098; PTHR23098; 1.
DR   Pfam; PF13873; Myb_DNA-bind_5; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Nucleus; Reference proteome.
FT   CHAIN           1..330
FT                   /note="Nuclear apoptosis-inducing factor 1"
FT                   /id="PRO_0000089723"
FT   REGION          1..74
FT                   /note="Required for nuclear localization and apoptosis-
FT                   inducing activity"
FT                   /evidence="ECO:0000250"
FT   REGION          92..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  36195 MW;  11A336D857E665BB CRC64;
     MASPPAPPAK KRKMNFSERE VEIIVEELER GKHLLINHFN AGVPLAAKAA AWHDILRRVN
     AVATCHRELP EVKKKWSDLK TEVRRKVAQV RAAMEGGGES QNGGGAGTEG EDPTGATAAP
     VILTPMQQRI CNLLGEATII SLPSGDCGAG RRDRDPHHRL RHHRHADPGV SAAPSEVPAE
     TTYHSLEDGV VEYCTTEAPT TVTAEAPLEM MAHQHEVSAK PQELKSRIAL NSAKLLQEQR
     VTNLHVKEIA QHLEQQNDLL QMIRRSQEVQ ACAQERQAQA MEGTQAALSA LIQVLRPMIK
     DFRRFLQSNT PSPSVTADPN QTGQQDGIIQ