ID   NAIF1_MACFA             Reviewed;         327 AA.
AC   Q9BE21;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Nuclear apoptosis-inducing factor 1;
GN   Name=NAIF1; ORFNames=QflA-15038, QtsA-10141;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC   -!- FUNCTION: Induces apoptosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HARBI1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAIF1 family. {ECO:0000305}.
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DR   EMBL; AB096992; BAC41239.1; -; mRNA.
DR   EMBL; AB060227; BAB41159.1; -; mRNA.
DR   RefSeq; NP_001306463.1; NM_001319534.1.
DR   AlphaFoldDB; Q9BE21; -.
DR   STRING; 9541.XP_005582189.1; -.
DR   GeneID; 102142403; -.
DR   CTD; 203245; -.
DR   eggNOG; ENOG502QW9U; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR028002; Myb_DNA-bind_5.
DR   InterPro; IPR026753; NAIF1.
DR   PANTHER; PTHR23098; PTHR23098; 1.
DR   Pfam; PF13873; Myb_DNA-bind_5; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Nucleus; Reference proteome.
FT   CHAIN           1..327
FT                   /note="Nuclear apoptosis-inducing factor 1"
FT                   /id="PRO_0000089725"
FT   REGION          1..70
FT                   /note="Required for nuclear localization and apoptosis-
FT                   inducing activity"
FT                   /evidence="ECO:0000250"
FT   REGION          87..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  35154 MW;  ADBC276E5FFDBD80 CRC64;
     MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT
     CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGSTE EDGAGGPGTG GGSGGGGPAV
     APVLLTPMQQ RICNLLGEAT IISLPSTTEI HPVALGPSAT AAAATVTLTQ IPTETTYHTL
     EEGVVEYCTA EAPPPLPPEA PVDMMAQHAD TSVKPQALKS RIALNSAKLI QEQRVTNLHV
     KEIAQHLEQQ NDLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQVLR PMIKDFRRYL
     QSNTANPAPT SDPGQVAQNG QPDSIIQ