NAIF1_MOUSE
ID NAIF1_MOUSE Reviewed; 327 AA.
AC Q6PFD7; A2ASZ4; Q8CEZ2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Nuclear apoptosis-inducing factor 1;
GN Name=Naif1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-327.
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Induces apoptosis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with HARBI1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NAIF1 family. {ECO:0000305}.
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DR EMBL; AL928710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057613; AAH57613.1; -; mRNA.
DR EMBL; AK009216; BAC25247.1; -; mRNA.
DR CCDS; CCDS15916.1; -.
DR RefSeq; NP_919316.1; NM_194335.2.
DR AlphaFoldDB; Q6PFD7; -.
DR SMR; Q6PFD7; -.
DR STRING; 10090.ENSMUSP00000048764; -.
DR iPTMnet; Q6PFD7; -.
DR PhosphoSitePlus; Q6PFD7; -.
DR EPD; Q6PFD7; -.
DR MaxQB; Q6PFD7; -.
DR PaxDb; Q6PFD7; -.
DR PeptideAtlas; Q6PFD7; -.
DR PRIDE; Q6PFD7; -.
DR ProteomicsDB; 293616; -.
DR Antibodypedia; 30951; 117 antibodies from 18 providers.
DR DNASU; 71254; -.
DR Ensembl; ENSMUST00000048431; ENSMUSP00000048764; ENSMUSG00000039164.
DR GeneID; 71254; -.
DR KEGG; mmu:71254; -.
DR UCSC; uc008jfr.1; mouse.
DR CTD; 203245; -.
DR MGI; MGI:1918504; Naif1.
DR VEuPathDB; HostDB:ENSMUSG00000039164; -.
DR eggNOG; ENOG502QW9U; Eukaryota.
DR GeneTree; ENSGT00450000040324; -.
DR HOGENOM; CLU_078961_0_0_1; -.
DR InParanoid; Q6PFD7; -.
DR OMA; EMIAQHA; -.
DR OrthoDB; 1169567at2759; -.
DR PhylomeDB; Q6PFD7; -.
DR TreeFam; TF332812; -.
DR BioGRID-ORCS; 71254; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q6PFD7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6PFD7; protein.
DR Bgee; ENSMUSG00000039164; Expressed in spermatid and 155 other tissues.
DR Genevisible; Q6PFD7; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
DR GO; GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; ISS:UniProtKB.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR InterPro; IPR026753; NAIF1.
DR PANTHER; PTHR23098; PTHR23098; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Nucleus; Reference proteome.
FT CHAIN 1..327
FT /note="Nuclear apoptosis-inducing factor 1"
FT /id="PRO_0000089726"
FT REGION 1..70
FT /note="Required for nuclear localization and apoptosis-
FT inducing activity"
FT /evidence="ECO:0000250"
FT REGION 87..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 35152 MW; 0D9326644E4718FE CRC64;
MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT
CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPTE DDGAGGPGTG SGSGGSGTAI
APVLLTPMQQ RICNLLGEAT IISLPSTTEI HPVALGSTAT TAAATVTLTQ IPTETTYHTL
EEGVVEYCTA EAPPPLPTEA PVEMIAQPPD TSVKPQALKS RIALNSAKLI QEQRVTNLHI
KEIAQHLEQQ NGLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQVLR PMIKDFRRYL
QNNTPNPAPA SAPGPVAQNG QPDSIIQ
