NAKR2_ARATH
ID NAKR2_ARATH Reviewed; 259 AA.
AC Q58FZ0; F4IQW1; Q8H1N1; Q9ZUS7;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein SODIUM POTASSIUM ROOT DEFECTIVE 2 {ECO:0000303|PubMed:21193571};
DE Short=NaKR2 {ECO:0000303|PubMed:21193571};
DE AltName: Full=Heavy metal-associated plant protein 3 {ECO:0000303|PubMed:23368984};
DE Short=AtHPP03 {ECO:0000303|PubMed:23368984};
GN Name=NAKR2 {ECO:0000303|PubMed:21193571};
GN Synonyms=HPP03 {ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At2g37390 {ECO:0000312|Araport:AT2G37390};
GN ORFNames=F3G5.18 {ECO:0000312|EMBL:AAC98058.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAX55145.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21193571; DOI=10.1105/tpc.110.080010;
RA Tian H., Baxter I.R., Lahner B., Reinders A., Salt D.E., Ward J.M.;
RT "Arabidopsis NPCC6/NaKR1 is a phloem mobile metal binding protein necessary
RT for phloem function and root meristem maintenance.";
RL Plant Cell 22:3963-3979(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q58FZ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q58FZ0-2; Sequence=VSP_058510;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC98058.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005896; AAC98058.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09391.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09392.1; -; Genomic_DNA.
DR EMBL; AY954819; AAX55145.1; -; mRNA.
DR EMBL; AY144105; AAN08440.1; -; mRNA.
DR PIR; B84792; B84792.
DR RefSeq; NP_001189699.1; NM_001202770.1. [Q58FZ0-2]
DR RefSeq; NP_181275.2; NM_129294.4. [Q58FZ0-1]
DR AlphaFoldDB; Q58FZ0; -.
DR SMR; Q58FZ0; -.
DR STRING; 3702.AT2G37390.1; -.
DR iPTMnet; Q58FZ0; -.
DR PaxDb; Q58FZ0; -.
DR PRIDE; Q58FZ0; -.
DR ProteomicsDB; 251043; -. [Q58FZ0-1]
DR DNASU; 818315; -.
DR EnsemblPlants; AT2G37390.1; AT2G37390.1; AT2G37390. [Q58FZ0-1]
DR EnsemblPlants; AT2G37390.2; AT2G37390.2; AT2G37390. [Q58FZ0-2]
DR GeneID; 818315; -.
DR Gramene; AT2G37390.1; AT2G37390.1; AT2G37390. [Q58FZ0-1]
DR Gramene; AT2G37390.2; AT2G37390.2; AT2G37390. [Q58FZ0-2]
DR KEGG; ath:AT2G37390; -.
DR Araport; AT2G37390; -.
DR TAIR; locus:2049731; AT2G37390.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_071922_0_0_1; -.
DR InParanoid; Q58FZ0; -.
DR OMA; QASTTIC; -.
DR OrthoDB; 1257261at2759; -.
DR PhylomeDB; Q58FZ0; -.
DR PRO; PR:Q58FZ0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q58FZ0; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR044526; NAKR1/2/3.
DR InterPro; IPR016578; NAKR2/3.
DR PANTHER; PTHR46119; PTHR46119; 1.
DR Pfam; PF00403; HMA; 1.
DR PIRSF; PIRSF011221; Chloropl_CC_prd; 1.
DR SUPFAM; SSF55008; SSF55008; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome.
FT CHAIN 1..259
FT /note="Protein SODIUM POTASSIUM ROOT DEFECTIVE 2"
FT /id="PRO_0000437274"
FT DOMAIN 180..246
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 141..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 191
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 194
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT VAR_SEQ 180
FT /note="Missing (in isoform 2)"
FT /id="VSP_058510"
FT CONFLICT 254
FT /note="V -> A (in Ref. 4; AAN08440)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 27868 MW; BE6302D8593EFE6A CRC64;
MKGRMFCASQ ASTAICSSMD HVHKSTTTDE DERNSGRAID RHNPIIKDGR RSFADDFIKL
PTSAEDGEMS NKKLEIYKGR RSITGRRSTG GGGGGGAAAL LKLITNDIGL ARKSFSCVAR
PACDLIKTPV GSTRYLLGSD PDSITGSVDQ DPAKTVEAEA PAGEDKTLTE KKTTCGDTDQ
QVVVLKVSLH CRGCEGKVRK HLARMQGVTS FNIDFAAKKV TVTGDITPLE ILDSISKVKN
AQFWTNPTIP KPNVETQNP
