NAL14_MOUSE
ID NAL14_MOUSE Reviewed; 993 AA.
AC Q6B966; B2RUL1; Q66X14;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 14;
DE Short=NALP-iota;
DE AltName: Full=Germ cell specific leucine-rich repeat NTPase;
GN Name=Nlrp14; Synonyms=Nalp14 {ECO:0000303|PubMed:15590904};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND
RP TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15590904; DOI=10.1095/biolreprod.104.033753;
RA Horikawa M., Kirkman N.J., Mayo K.E., Mulders S.M., Zhou J., Bondy C.A.,
RA Hsu S.Y., King G.J., Adashi E.Y.;
RT "The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member
RT of the NACHT nucleoside triphosphatase family.";
RL Biol. Reprod. 72:879-889(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-993.
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
CC -!- FUNCTION: May be involved in inflammation and spermatogenesis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15590904}.
CC -!- TISSUE SPECIFICITY: Detected in adult ovary and testis. Detected in
CC oocytes and in germ cell elements in seminiferous tubules in adult
CC testis (at protein level). {ECO:0000269|PubMed:15590904}.
CC -!- DEVELOPMENTAL STAGE: Not detected in ovaries from neonates. First
CC detected in ovaries three days after birth, and expression in ovaries
CC increases dramatically to reach a much higher level eight days after
CC birth. {ECO:0000269|PubMed:15590904}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT77542.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY673647; AAT77542.1; ALT_INIT; mRNA.
DR EMBL; BC141199; AAI41200.1; -; mRNA.
DR EMBL; AY596199; AAU06320.1; -; mRNA.
DR CCDS; CCDS21688.1; -.
DR RefSeq; NP_001002894.2; NM_001002894.2.
DR RefSeq; XP_011240240.1; XM_011241938.1.
DR AlphaFoldDB; Q6B966; -.
DR SMR; Q6B966; -.
DR BioGRID; 218354; 1.
DR IntAct; Q6B966; 1.
DR MINT; Q6B966; -.
DR STRING; 10090.ENSMUSP00000081819; -.
DR iPTMnet; Q6B966; -.
DR PhosphoSitePlus; Q6B966; -.
DR PaxDb; Q6B966; -.
DR PRIDE; Q6B966; -.
DR ProteomicsDB; 293617; -.
DR Antibodypedia; 42308; 53 antibodies from 22 providers.
DR DNASU; 76858; -.
DR Ensembl; ENSMUST00000084763; ENSMUSP00000081819; ENSMUSG00000016626.
DR GeneID; 76858; -.
DR KEGG; mmu:76858; -.
DR UCSC; uc009jax.2; mouse.
DR CTD; 338323; -.
DR MGI; MGI:1924108; Nlrp14.
DR VEuPathDB; HostDB:ENSMUSG00000016626; -.
DR eggNOG; ENOG502QS9E; Eukaryota.
DR GeneTree; ENSGT00940000162005; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; Q6B966; -.
DR OMA; MISKDWP; -.
DR OrthoDB; 114368at2759; -.
DR PhylomeDB; Q6B966; -.
DR BioGRID-ORCS; 76858; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q6B966; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6B966; protein.
DR Bgee; ENSMUSG00000016626; Expressed in primary oocyte and 22 other tissues.
DR ExpressionAtlas; Q6B966; baseline and differential.
DR Genevisible; Q6B966; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; ISO:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13516; LRR_6; 5.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cytoplasm; Developmental protein; Differentiation;
KW Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat;
KW Spermatogenesis.
FT CHAIN 1..993
FT /note="NACHT, LRR and PYD domains-containing protein 14"
FT /id="PRO_0000286339"
FT DOMAIN 81..403
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 636..657
FT /note="LRR 1"
FT REPEAT 660..680
FT /note="LRR 2"
FT REPEAT 688..708
FT /note="LRR 3"
FT REPEAT 717..738
FT /note="LRR 4"
FT REPEAT 745..765
FT /note="LRR 5"
FT REPEAT 774..795
FT /note="LRR 6"
FT REPEAT 802..822
FT /note="LRR 7"
FT REPEAT 831..852
FT /note="LRR 8"
FT REPEAT 859..879
FT /note="LRR 9"
FT BINDING 87..94
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT CONFLICT 669
FT /note="C -> R (in Ref. 3; AAU06320)"
FT /evidence="ECO:0000305"
FT CONFLICT 689
FT /note="L -> S (in Ref. 1; AAT77542)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 993 AA; 113386 MW; 0C48C366EF8015C3 CRC64;
MKTEDDEMEY EASKEETVSE DKDFDDGIDY RTVIKENIFT MWYKTSLHGE FATLNCVITP
KDQNLLQHIF DEDIQTSEAP QTVVLQGAAG IGKTTLLKKA VLEWADGNLY QQFTHVFYLN
GKEISQVKEK SFAQLISKHW PSSEGPIEQV LSKPSSLLFI IDSFDELDFS FEEPQFALCK
DWTQISPVSF LISSLLRKVM LPESYLLVAT RSTAWKRLVP LLQKPQRVKL SGLSKNARMD
YIHHLLKDKA WATSAIYSLR MNWRLFHMCH VCHMCQMICA VLKGQVEKGG RVEETCKTST
ALFTYYICSL FPRIPVGCVT LPNETLLRSL CKAAVEGIWT MKHVLYQQNL RKHELTREDI
LLFLDAKVLQ QDTEYENCYM FTHLHVQEFF AALFYLLREN LEEQDYPSEP FENLYLLLES
NHIHDPHLEQ MKCFLFGLLN KDRVRQLEET FNLTISMEVR EELLACLEGL EKDDSSLSQL
RFQDLLHCIY ETQDQEFITQ ALMYFQKIIV RVDEEPQLRI YSFCLKHCHT LKTMRLTARA
DLKNMLDTAE MCLEGAAVQV IHYWQDLFSV LHTNESLIEM DLYESRLDES LMKILNEELS
HPKCKLQKLI FRAVDFLNGC QDFTFLASNK KVTHLDLKET DLGVNGLKTL CEALKCKGCK
LRVLRLASCD LNVARCQKLS NALQTNRSLV FLNLSLNNLS NDGVKSLCEV LENPNSSLER
LALASCGLTK AGCKVLSSAL TKSKRLTHLC LSDNVLEDEG IKLLSHTLKH PQCTLQSLVL
RSCSFTPIGS EHLSTALLHN RSLVHLDLGQ NKLADNGVKL LCHSLQQPHC NLQELELMSC
VLTSKACGDL ASVLVNNSNL WSLDLGHNIL DDAGLNILCD ALRNPNCHVQ RLGLENCGLT
PGCCQDLLGI LSNNKSVIQM NLMKNALDHE SIKNLCKVLR SPTCKMEFLA LDKKEILKKK
IKKFLVDVRI NNPHLVIGPE CPNTESGCWW NYF
