ID   NAL4A_MOUSE             Reviewed;         982 AA.
AC   Q8BU40;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=NACHT, LRR and PYD domains-containing protein 4A;
DE            Short=NALP-ita;
GN   Name=Nlrp4a; Synonyms=Nalp4a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA   Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA   Dudekula D.B., VanBuren V., Ko M.S.H.;
RT   "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL   Hum. Mol. Genet. 13:2263-2278(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Martinon F., Hofmann K., Tschopp J.;
RT   "Murine NALPs: a family of proteins involved in inflammation.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Ovary;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: May be involved in inflammation and recognition of cytosolic
CC       pathogen-associated molecular patterns (PAMPs) not intercepted by
CC       membrane-bound receptors. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR   EMBL; AY596200; AAU06321.1; -; mRNA.
DR   EMBL; AY355341; AAR14738.1; -; mRNA.
DR   EMBL; AK087843; BAC40024.1; -; mRNA.
DR   CCDS; CCDS21003.1; -.
DR   RefSeq; NP_766484.1; NM_172896.2.
DR   RefSeq; XP_011248868.1; XM_011250566.1.
DR   AlphaFoldDB; Q8BU40; -.
DR   SMR; Q8BU40; -.
DR   STRING; 10090.ENSMUSP00000066841; -.
DR   iPTMnet; Q8BU40; -.
DR   PhosphoSitePlus; Q8BU40; -.
DR   MaxQB; Q8BU40; -.
DR   PaxDb; Q8BU40; -.
DR   PRIDE; Q8BU40; -.
DR   ProteomicsDB; 287432; -.
DR   DNASU; 243880; -.
DR   Ensembl; ENSMUST00000068767; ENSMUSP00000066841; ENSMUSG00000040601.
DR   Ensembl; ENSMUST00000119386; ENSMUSP00000112441; ENSMUSG00000040601.
DR   GeneID; 243880; -.
DR   KEGG; mmu:243880; -.
DR   UCSC; uc009ful.1; mouse.
DR   CTD; 243880; -.
DR   MGI; MGI:2443697; Nlrp4a.
DR   VEuPathDB; HostDB:ENSMUSG00000040601; -.
DR   eggNOG; ENOG502SGVH; Eukaryota.
DR   GeneTree; ENSGT00940000162284; -.
DR   HOGENOM; CLU_002274_2_1_1; -.
DR   InParanoid; Q8BU40; -.
DR   OMA; FYFCCQE; -.
DR   OrthoDB; 114368at2759; -.
DR   PhylomeDB; Q8BU40; -.
DR   BioGRID-ORCS; 243880; 0 hits in 70 CRISPR screens.
DR   ChiTaRS; Nlrp4a; mouse.
DR   PRO; PR:Q8BU40; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8BU40; protein.
DR   Bgee; ENSMUSG00000040601; Expressed in primary oocyte and 9 other tissues.
DR   ExpressionAtlas; Q8BU40; baseline and differential.
DR   Genevisible; Q8BU40; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Inflammatory response; Leucine-rich repeat;
KW   Nucleotide-binding; Reference proteome; Repeat.
FT   CHAIN           1..982
FT                   /note="NACHT, LRR and PYD domains-containing protein 4A"
FT                   /id="PRO_0000286329"
FT   DOMAIN          1..93
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT   DOMAIN          148..471
FT                   /note="NACHT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   REPEAT          594..618
FT                   /note="LRR 1"
FT   REPEAT          634..658
FT                   /note="LRR 2"
FT   REPEAT          689..712
FT                   /note="LRR 3"
FT   REPEAT          746..773
FT                   /note="LRR 4"
FT   REPEAT          777..801
FT                   /note="LRR 5"
FT   REPEAT          802..825
FT                   /note="LRR 6"
FT   REPEAT          827..847
FT                   /note="LRR 7"
FT   REPEAT          859..882
FT                   /note="LRR 8"
FT   REPEAT          888..911
FT                   /note="LRR 9"
FT   REPEAT          916..943
FT                   /note="LRR 10"
FT   BINDING         154..161
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
SQ   SEQUENCE   982 AA;  112601 MW;  6E2DBCFEA2053585 CRC64;
     MASFFSDFGL MWYLEELNKK EFVKFKEFLK QEVLQLGLKQ VSWTEVKKAS RQDLASLLLK
     HYEEKPAWDM TFRFFQKINR KDLIERAKRE IDGCPKLYRA HMKTKMTHDS SRAFTISIQN
     FLKEKFTEDD YDCFENLFQS KGTESKPQVV FLSGGAGVGK TLMLKRLMLA WIESPVFLHK
     FSYIFYFCCR EVKQLKTASL AELISREWPG PSAPIEEILS KPEKLLFIID SLEGMECDLF
     KWESELCDNC TEKQPVNVLL SSLLRRKMLP ESSLLISATP ESFEKMENRI EYTHVKIIKG
     LKERNIKMSF HRLFQDRNRA HEAFSLVREN EQLFTVCQVP VLCWMVATCL KEEIEKGRDP
     VSICRCTTSL YTTHIFNLFI PQNAHSPSKK SQDQLQGLCS LAAEGMWTDT FVFGEEALRR
     NGIMDSDIPI LLDIGMLINI RESEKSYIFL HPSVQEVCAA IFYLLKSHVD HPSQEVKSIE
     KLMFAFLKKV KVQWIFFGSF IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE
     ELQEQIDGMK LFYCLFEMDD DTFLVEAMNC MEQINFVAKD YSDVIVAAHC LKHCFTLKKL
     SFSTQNVLSG AQEHSYMERL LTAWNHICSV FIISKDIQEL RMKDTNLSES AFSVLYNNLK
     YHNYTLNVLV ANNVFFVCEK YLFFELIQNC NLQHLNLSLT ILSHSDVKLL CDVLSQAECN
     IEELVVAACS ISSDDCKVFA SVLISNKTLK HLNLASNTLD KGIASLCKSL CHPDCILEHL
     VLANCSLNEK CWDYLSEVLR RNKTLSHLDI SSNDLKDEGL KVLCRALTLP DSVLKSLSLR
     HCLITISGCQ DLAEVLRNNQ NLVSLQVSNN KLEDTGVKLL CDAIKHPNCH LEDLGLEACE
     LTGACCEDLA STFTQCKTLW AMNLLKNALD YNGLVVLCEA LKQQTCATYV LGLQITDFDT
     ETQAFLVAEQ EKNPCLRILS SL