NAL4B_MOUSE
ID NAL4B_MOUSE Reviewed; 863 AA.
AC Q8C6J9; Q66X16;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 4B;
DE AltName: Full=NALP-gamma;
GN Name=Nlrp4b; Synonyms=Nalp4b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Martinon F., Hofmann K., Tschopp J.;
RT "Murine NALPs: a family of proteins involved in inflammation.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in inflammation and recognition of cytosolic
CC pathogen-associated molecular patterns (PAMPs) not intercepted by
CC membrane-bound receptors. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR EMBL; AY596198; AAU06319.1; -; mRNA.
DR EMBL; AY355342; AAR14739.1; -; mRNA.
DR EMBL; AK054426; BAC35775.1; -; mRNA.
DR CCDS; CCDS20795.1; -.
DR RefSeq; NP_766069.1; NM_172481.2.
DR RefSeq; XP_006539767.1; XM_006539704.1.
DR AlphaFoldDB; Q8C6J9; -.
DR SMR; Q8C6J9; -.
DR STRING; 10090.ENSMUSP00000113095; -.
DR iPTMnet; Q8C6J9; -.
DR PhosphoSitePlus; Q8C6J9; -.
DR PaxDb; Q8C6J9; -.
DR PRIDE; Q8C6J9; -.
DR ProteomicsDB; 287605; -.
DR DNASU; 210045; -.
DR Ensembl; ENSMUST00000047809; ENSMUSP00000043881; ENSMUSG00000034087.
DR Ensembl; ENSMUST00000117413; ENSMUSP00000113095; ENSMUSG00000034087.
DR GeneID; 210045; -.
DR KEGG; mmu:210045; -.
DR UCSC; uc009fdi.1; mouse.
DR CTD; 210045; -.
DR MGI; MGI:3056570; Nlrp4b.
DR VEuPathDB; HostDB:ENSMUSG00000034087; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000162284; -.
DR HOGENOM; CLU_002274_2_3_1; -.
DR InParanoid; Q8C6J9; -.
DR OMA; GISHESN; -.
DR OrthoDB; 114368at2759; -.
DR PhylomeDB; Q8C6J9; -.
DR BioGRID-ORCS; 210045; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Nlrp4b; mouse.
DR PRO; PR:Q8C6J9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C6J9; protein.
DR Bgee; ENSMUSG00000034087; Expressed in primary oocyte and 6 other tissues.
DR ExpressionAtlas; Q8C6J9; baseline and differential.
DR Genevisible; Q8C6J9; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Inflammatory response; Leucine-rich repeat;
KW Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..863
FT /note="NACHT, LRR and PYD domains-containing protein 4B"
FT /id="PRO_0000286330"
FT DOMAIN 1..93
FT /note="Pyrin"
FT DOMAIN 143..466
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 618..643
FT /note="LRR 1"
FT REPEAT 683..706
FT /note="LRR 2"
FT REPEAT 717..740
FT /note="LRR 3"
FT REPEAT 741..763
FT /note="LRR 4"
FT REPEAT 765..782
FT /note="LRR 5"
FT REPEAT 797..824
FT /note="LRR 6"
FT REPEAT 843..863
FT /note="LRR 7"
FT BINDING 149..156
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT CONFLICT 6
FT /note="S -> L (in Ref. 1; AAU06319)"
FT /evidence="ECO:0000305"
FT CONFLICT 657
FT /note="S -> C (in Ref. 1; AAU06319)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 863 AA; 99955 MW; D3A46C782DA544CF CRC64;
MASLFSDFGF IWYWKELNKI EFMYFKELLI HEILQMGLKQ ISWTEVKEAS REDLAILLVK
HCDGNQAWDT TFRVFQMIGR NVITNRATGE IAAHSTIYRA HLKEKLTHDC SRKFNISIQN
FFQDEYDHLE NLLVPNGTEN NPKMVVLQGV AGIGKTILLK NLMIVWSEGL VFQNKFSYIF
YFCCHDVKQL QTASLADLIS REWPSPSAPM EEILSQPEKL LFIIDSLEGM EWNVTQQDSQ
LCYNCMEKQP VNVLLSSLLR KKILPESSLL ISTSCETFKD LKDWIEYTNV RTITGFKENN
INMCFHSLFQ DRNIAQEAFS LIRENEQLFT VCQAPVVCYM VATCLKNEIE SGKDPVSICR
RTTSLYTTHI LNLFIPHNAQ NPSNNSEDLL DNLCFLAVEG MWTDISVFNE EALRRNGIMD
SDIPTLLDIG ILEQSRESEN SYIFLHPSVQ EFCAAMFYLL HSEMDHSCQG VYFIETFLFT
FLNKIKKQWV FLGCFFFGLL HETEQEKLEA FFGYHLSKEL RRQLFLWLEL LLDTLHPDVK
KINTMKFFYC LFEMEEEVFV QSAMNCREQI DVVVKGYSDF IVAAYCLSHG SALTDFSISA
QNVLNEELGQ RGKLLILWHQ ICSVFLRNKD IKTLRIEDTI FNEPVFKIFY SYLKNSSCIL
KTLVAYNVSF LCDKRLFLEL IQSYNLEELY LRGTFLSHSD VEMLCDILNQ AECNIRILDL
ANCSLCEHSW DYLSDVLRQN KSLRYLNISY NNLKDEGLKA LCRALTLPNS ALHSLSLEAC
QLTGACCKDL ASTFTRYKCL RRINLAKNSL GFSGLFVLCK AMKDQTCTLY ELKLRMADFD
SDSQEFLLSE MERNKILSIE NGV
