NAL4E_MOUSE
ID NAL4E_MOUSE Reviewed; 978 AA.
AC Q66X19;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 4E;
DE AltName: Full=NALP-epsilon;
GN Name=Nlrp4e; Synonyms=Nalp4e, Nlrp4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May be involved in inflammation and recognition of cytosolic
CC pathogen-associated molecular patterns (PAMPs) not intercepted by
CC membrane-bound receptors. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR EMBL; AY596197; AAU06318.1; -; mRNA.
DR EMBL; AC150900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS20928.1; -.
DR RefSeq; NP_001004194.2; NM_001004194.2.
DR AlphaFoldDB; Q66X19; -.
DR SMR; Q66X19; -.
DR STRING; 10090.ENSMUSP00000075794; -.
DR MaxQB; Q66X19; -.
DR PaxDb; Q66X19; -.
DR PRIDE; Q66X19; -.
DR ProteomicsDB; 287433; -.
DR DNASU; 446099; -.
DR Ensembl; ENSMUST00000076470; ENSMUSP00000075794; ENSMUSG00000045693.
DR GeneID; 446099; -.
DR KEGG; mmu:446099; -.
DR UCSC; uc009fod.2; mouse.
DR CTD; 446099; -.
DR MGI; MGI:3056600; Nlrp4e.
DR VEuPathDB; HostDB:ENSMUSG00000045693; -.
DR eggNOG; ENOG502SGVH; Eukaryota.
DR GeneTree; ENSGT00940000162284; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; Q66X19; -.
DR OMA; GCITHIV; -.
DR OrthoDB; 1580402at2759; -.
DR PhylomeDB; Q66X19; -.
DR BioGRID-ORCS; 446099; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Nlrp4e; mouse.
DR PRO; PR:Q66X19; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q66X19; protein.
DR Bgee; ENSMUSG00000045693; Expressed in animal zygote and 10 other tissues.
DR Genevisible; Q66X19; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Inflammatory response; Leucine-rich repeat;
KW Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..978
FT /note="NACHT, LRR and PYD domains-containing protein 4E"
FT /id="PRO_0000286332"
FT DOMAIN 1..93
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 148..471
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 594..617
FT /note="LRR 1"
FT REPEAT 694..717
FT /note="LRR 2"
FT REPEAT 746..773
FT /note="LRR 3"
FT REPEAT 802..825
FT /note="LRR 4"
FT REPEAT 859..882
FT /note="LRR 5"
FT REPEAT 916..940
FT /note="LRR 6"
FT BINDING 154..161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT CONFLICT 135
FT /note="E -> G (in Ref. 1; AAU06318)"
FT /evidence="ECO:0000305"
FT CONFLICT 590
FT /note="C -> S (in Ref. 1; AAU06318)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 978 AA; 112473 MW; 24A25AFF43FFE933 CRC64;
MASFFSDFGL MWYLEELNKK EFMKFKELLQ QEILQLGLKH ISWTEVKKAS REDLANLLLK
HYEEKKAWDM TFKIFQKMNR QDLMERAGRE IAGHSKLYQV HLKKKLTHDY ARKFNIKDQD
SLKQKFTQDD CDHFENLLIS KATGKKPHMV FLQGVAGIGK SLMLTKLMLA WSEGMVFQNK
FSYIFYFCCQ DVKKMKRASL AELISKEWPN ASAPIEEILS QPEKLLFVID NLEVMECDMS
EWESELCDDC MEKQPVNILM SSLLRRKMLP ESSFLVSATP ETFEKIEDRI ECTNVKMMAG
FNESSIKVYF YSLFQDRNRT QEIFSLVREN EQLFSVCQVP VLCWMVATCL KKEIEKGRDP
VSICRRITSL YTTYIFNLFI PHSAQYPSKK SQDQLQGLCS LAAEGMWTDT FVFAEEALRR
NGIMDSDIST LLDVRILEKS KESEKSYIFL HPSIQEVCAA IFHLLKSHVD HPSQDVKSIE
ALIFTFLKKV KIQWIFFGSF IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNK
ELQEQIDGMK LFYCLFEMDD EAFLPQVMNC MEQIKFVAKD YSDVIVAAHC LQHCSTLKKL
SLSTQNILSE GQEHSYTEKL LICWHHVCSV LTSSKDIHVL QVKDTNFNER AFLVLYSHLK
YPSCILKVLE VNNVTLLCDN RLLFELIQNQ RLQLLNLSLT FLSHNDVKLL CDVLNQAECN
IEKLMVADCN LSPDDCKVFV SVLISSKMLK HLNLSSNNLD KGISSLSKAL CHPDCVLKNL
VLAKCSLSEE CWHYLSEVLR RNKTLTHLDI SFNDLKDEGL KVLCGALTLP DSVLISLSVR
YCLITTSGCQ DLAEVLRNNQ NLRNLQISNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA
LTGACCEDLA SSFTHCKTLL GINLQENALD HSGLVALFEA MKQQQCTVNL RGLRITDFDK
ETQEFLMAEK EKNPYLSI
