NAL4F_MOUSE
ID NAL4F_MOUSE Reviewed; 959 AA.
AC Q66X05;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 4F;
DE AltName: Full=NALP-kappa;
GN Name=Nlrp4f; Synonyms=Nalp4f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
RN [2]
RP FUNCTION, INTERACTION WITH TLE6 AND OOEP, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=31575650; DOI=10.1242/dev.183616;
RA Qin D., Gao Z., Xiao Y., Zhang X., Ma H., Yu X., Nie X., Fan N., Wang X.,
RA Ouyang Y., Sun Q.Y., Yi Z., Li L.;
RT "The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic
RT lattice formation and organelle distribution.";
RL Development 146:0-0(2019).
CC -!- FUNCTION: Required for cytoplasmic lattice formation, thereby modulates
CC the distribution of organelles during oocyte maturation and zygote
CC development (PubMed:31575650). Required for preimplantation development
CC in female fertility (PubMed:31575650). May be involved in inflammation
CC and recognition of cytosolic pathogen-associated molecular patterns
CC (PAMPs) not intercepted by membrane-bound receptors (By similarity).
CC {ECO:0000250|UniProtKB:Q96MN2, ECO:0000269|PubMed:31575650}.
CC -!- SUBUNIT: Associates with the subcortical maternal complex (SCMC)
CC composed of at least NLRP5, KHDC3, OOEP, and TLE6 via interaction with
CC OOEP and TLE6. {ECO:0000269|PubMed:31575650}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31575650}.
CC Note=Expressed and colocalizes with NLRP5 at the oocyte subcortex.
CC {ECO:0000269|PubMed:31575650}.
CC -!- TISSUE SPECIFICITY: Expressed in the ovaries (at protein level).
CC {ECO:0000269|PubMed:31575650}.
CC -!- DEVELOPMENTAL STAGE: Abundantly expressed in one-cell stage embryos
CC with decreasing expression in the morula stage, expression in the
CC blastocyst is considerably lower (PubMed:31575650). Expressed in the
CC ovaries from birth, expression peaks at postnatal day 10 (P10),
CC expression is then decreased at P17 and further decreased at P21
CC (PubMed:31575650). {ECO:0000269|PubMed:31575650}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, however female mice produce
CC fewer offspring. Delay in embryo compaction and blastocyst cavitation
CC (PubMed:31575650). Disorganization of the mitochondria in zygotes
CC around the pronucleus and subcortical region following nuclear envelope
CC breakdown. During oocyte maturation the endoplasmic reticulum and
CC mitochondria are aberrantly distributed in the nucleus and cortical
CC region at the germinal vesicle stage, in the subcortical region after
CC germinal vesicle break down and dispersed throughout the cytoplasm at
CC the M2 stage (PubMed:31575650). Loss of cytoplasmic lattices in oocytes
CC (PubMed:31575650). {ECO:0000269|PubMed:31575650}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR EMBL; AY596201; AAU06322.1; -; mRNA.
DR STRING; 10090.ENSMUSP00000041908; -.
DR iPTMnet; Q66X05; -.
DR PhosphoSitePlus; Q66X05; -.
DR EPD; Q66X05; -.
DR PRIDE; Q66X05; -.
DR ProteomicsDB; 286147; -.
DR MGI; MGI:2145528; Nlrp4f.
DR eggNOG; ENOG502SGVH; Eukaryota.
DR InParanoid; Q66X05; -.
DR PhylomeDB; Q66X05; -.
DR ChiTaRS; Nlrp4f; mouse.
DR PRO; PR:Q66X05; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q66X05; protein.
DR GO; GO:0005938; C:cell cortex; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0007015; P:actin filament organization; IMP:UniProtKB.
DR GO; GO:0051656; P:establishment of organelle localization; IMP:UniProtKB.
DR GO; GO:0001701; P:in utero embryonic development; IMP:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cytoplasm; Inflammatory response; Leucine-rich repeat;
KW Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..959
FT /note="NACHT, LRR and PYD domains-containing protein 4F"
FT /id="PRO_0000286338"
FT DOMAIN 1..92
FT /note="Pyrin"
FT DOMAIN 147..470
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 593..616
FT /note="LRR 1"
FT REPEAT 632..656
FT /note="LRR 2"
FT REPEAT 686..709
FT /note="LRR 3"
FT REPEAT 715..738
FT /note="LRR 4"
FT REPEAT 743..766
FT /note="LRR 5"
FT REPEAT 812..835
FT /note="LRR 6"
FT REPEAT 841..864
FT /note="LRR 7"
FT REPEAT 869..892
FT /note="LRR 8"
FT BINDING 153..160
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
SQ SEQUENCE 959 AA; 110368 MW; F498305629D9CD48 CRC64;
MASFISDFGL IWYLRELNKK EFMKFKDFLI QEILELKLKQ VSSTKVKKAS REDLANLLLK
CGENQAWDMT FRILQKINRK DLTERATGAI VGNPNLYRDH LKKKLTHDCP KKFNVRIQDF
IKETFIQNDX DAFENLLISK GTERKPHMVF LKGMAGVGKT LMLKNLMLAW SKGLVFQNKF
SYAFYFCCQD VKQLKTASLA ELISREWPSP SAPIEEILSQ PEKLLFIIDS LEGMEWDLTK
QESELCDDCM EKQPVSTLLS SLLRRKMLPE SSLLLSTTPE TFEKMEDRIQ CTDVKTATAF
DERSMKIYFH RLFQDRKRAQ EAFSLVRENK QLFTICQVPL LCWMVATCLK EEIEKGGDPV
SLCRRTTSLY TTHIFSLFIP QSAQYPSKKS QDQLQGLCSL AAEGMWTDTF VFGKEALRRN
GIFDSDIPTL LDIGMLGKIR EFENSYIFLH PSVQEVCAAI FYMLKRHVEH PSQDVKNIET
VLFMFLKKVK TQWIFLGCFI FGLLQKSEQE KLGVFFGHRL SKNIHHKLYQ CLETLSGNAE
LQEQIDGMRL FSCLFEMEDE AFLVKAMNCM QQINFVAKNY SDFIVAAYCL KHCSTLKKLS
FSTENVLNEG DQSYMEELLI CWNNMCSVFV RSKDIQELRI KDTNFNEPAI RVLYESLKYP
SFTLNKLVAN NVSFGDNHVL FELIQNSSLQ YLDLSCSFLS HNEVKLLCDI LNQAECNIEK
LMIAHCKLSP DDCKIFGSIL MSSKSLKVLN LASNNLNQGI SSLCKALCHP HCTLEYLVPR
SNHCIVNFLL KLSCCGITER GCQDLAEVLK NNQNLKYLHV SYNKLKDTGV MLLCDAIKHP
NCHLKDLQLE ACEITDASNE ELCYAFMQCE TLQTLNLMGN AFEVSRMVFF PRKSELMLFI
FLHLSRLWIT DFDNEFQAFL LSVKKKNHFL TIRGSVEADG EKKGGDSDAR TMGELSNEI
