ID   NALF1_BOVIN             Reviewed;         457 AA.
AC   A4IFM1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=NALCN channel auxiliary factor 1;
DE   AltName: Full=Transmembrane protein FAM155A;
GN   Name=NALF1; Synonyms=FAM155A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Auxillary component of the NALCN sodium channel complex, a
CC       channel that regulates the resting membrane potential and controls
CC       neuronal excitability. {ECO:0000250|UniProtKB:B1AL88}.
CC   -!- SUBUNIT: Component of the NALCN channel complex. NALCN complex consists
CC       of NALCN and auxiliary subunits, UNC79, UNC80 and NACL1. These
CC       auxiliary subunits are essential for the NALCN channel function.
CC       {ECO:0000250|UniProtKB:B1AL88}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B1AL88};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the NALF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC134647; AAI34648.1; -; mRNA.
DR   RefSeq; NP_001077245.1; NM_001083776.1.
DR   AlphaFoldDB; A4IFM1; -.
DR   SMR; A4IFM1; -.
DR   STRING; 9913.ENSBTAP00000001416; -.
DR   PaxDb; A4IFM1; -.
DR   Ensembl; ENSBTAT00000001416; ENSBTAP00000001416; ENSBTAG00000025220.
DR   GeneID; 616912; -.
DR   KEGG; bta:616912; -.
DR   CTD; 728215; -.
DR   VEuPathDB; HostDB:ENSBTAG00000025220; -.
DR   VGNC; VGNC:28735; NALF1.
DR   eggNOG; ENOG502QQKW; Eukaryota.
DR   GeneTree; ENSGT00940000155696; -.
DR   HOGENOM; CLU_058453_0_0_1; -.
DR   InParanoid; A4IFM1; -.
DR   OMA; TQKYEPG; -.
DR   OrthoDB; 1585247at2759; -.
DR   TreeFam; TF331752; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000025220; Expressed in Ammon's horn and 56 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR   InterPro; IPR029604; NALF1/2.
DR   PANTHER; PTHR15819:SF9; PTHR15819:SF9; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..457
FT                   /note="NALCN channel auxiliary factor 1"
FT                   /id="PRO_0000339372"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          70..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        216
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        187..260
FT                   /evidence="ECO:0000250|UniProtKB:Q8CCS2"
FT   DISULFID        225..312
FT                   /evidence="ECO:0000250|UniProtKB:B1AL88"
FT   DISULFID        245..260
FT                   /evidence="ECO:0000250|UniProtKB:B1AL88"
FT   DISULFID        303..340
FT                   /evidence="ECO:0000250|UniProtKB:B1AL88"
FT   DISULFID        323..376
FT                   /evidence="ECO:0000250|UniProtKB:B1AL88"
FT   DISULFID        329..375
FT                   /evidence="ECO:0000250|UniProtKB:B1AL88"
FT   DISULFID        333..360
FT                   /evidence="ECO:0000250|UniProtKB:B1AL88"
SQ   SEQUENCE   457 AA;  50897 MW;  D8C77A2229AB9EDA CRC64;
     MTRGAWMCRQ YDDGLKIWLA APRENEKPFI DSERAQKWRL SLASLLFFTV LLSDHLWFCA
     EAKLTRARDK EQQQQQQQQQ QRQQRQRQEQ RQRQRQHEPS WPALLASMGE PSPAAQAHRL
     LSASPSPTLP PSLGGGGGGK GGRGTDSRGK PPLPGNSARP AWRLETCYPQ GASSGQCFTV
     DSADAVCARN WSRGAAARGE QGQQTRGPPQ PTPLWNLSDF YLSFCNSYTL WELFSGLSSP
     NTLNCSLDVV LKEGGEMTTC RQCVEAYQDY DHHAQEKYEE FESVLHKYLQ SEEYSVKSCP
     EDCKIVYKAW LCSQYFEVAQ LNCRKTIPCK QYCLEVQTRC PFILPDNDEV IYGGLSSFIC
     TGLYETFLTN DEPECCDVRR EAKPKSPSKG AGDRGGACPR TSLSASSAPR LGPSRLRLCV
     LVLMLLHTVL TASVAHNATA LGVGGVHTLD ERSASEE