NALF2_DANRE
ID NALF2_DANRE Reviewed; 401 AA.
AC A2AWH2; A1L1T2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=NALCN channel auxiliary factor 2;
DE AltName: Full=Transmembrane protein FAM155B;
GN Name=nalf2; Synonyms=fam155b {ECO:0000305};
GN ORFNames=si:dkey-48f17.1, zgc:158322;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable component of the NALCN channel complex, a channel
CC that regulates the resting membrane potential and controls neuronal
CC excitability. {ECO:0000250|UniProtKB:O75949}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NALF family. {ECO:0000305}.
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DR EMBL; AL954373; CAM16112.1; -; Genomic_DNA.
DR EMBL; BC129201; AAI29202.1; -; mRNA.
DR RefSeq; NP_001074112.2; NM_001080643.2.
DR AlphaFoldDB; A2AWH2; -.
DR SMR; A2AWH2; -.
DR STRING; 7955.ENSDARP00000078899; -.
DR PaxDb; A2AWH2; -.
DR Ensembl; ENSDART00000084464; ENSDARP00000078899; ENSDARG00000060152.
DR GeneID; 791161; -.
DR KEGG; dre:791161; -.
DR CTD; 27112; -.
DR ZFIN; ZDB-GENE-060526-303; nalf2.
DR eggNOG; ENOG502QQKW; Eukaryota.
DR GeneTree; ENSGT00940000161362; -.
DR HOGENOM; CLU_058453_0_0_1; -.
DR InParanoid; A2AWH2; -.
DR OMA; CTDSHSH; -.
DR OrthoDB; 1585247at2759; -.
DR PhylomeDB; A2AWH2; -.
DR TreeFam; TF331752; -.
DR PRO; PR:A2AWH2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000060152; Expressed in brain and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR029604; NALF1/2.
DR PANTHER; PTHR15819:SF8; PTHR15819:SF8; 3.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..401
FT /note="NALCN channel auxiliary factor 2"
FT /id="PRO_0000339375"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 76
FT /note="N -> S (in Ref. 2; AAI29202)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 401 AA; 44746 MW; F895FC1ABFCB61C3 CRC64;
MITGAWRCGR KLDAELEICR VTEPIDKPCA ESEKVQRWRM SLASLLFFTA LLSDHLWLCA
GGKLRSRDRT HRRTWNNASH DAQTGLRDED CGVLLSNLTE NGPDCVEADA RRRAPLESAC
STLYRQKSGS VSSSYSVTVP TVSPHAFLEY FRNFSLSFCD ALTIADLLES MTSPDGLNCS
LTHIIRDLFS GGPEDGDACS ACVHAYTRLD QHAQEKYEEF DALTRKYMAD DYSVRAQTHL
CQVVYKAWLC AEYFPVPQRQ CVRWLPCRHY CGEVTATCPF ILPDNDRLLY AGSPSFLCAG
FQEEYLSSQG PDCCDVRWSG CDSAVGAACA LTHLPGSFSF HRRLSSGAMS CTNRLHGSKL
KLCVLVLFLL HTFISITTLQ HCSTGSLEAI VPLEEVPMRE E
