ID   NALF2_MOUSE             Reviewed;         471 AA.
AC   A2BDP1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=NALCN channel auxiliary factor 2;
DE   AltName: Full=Protein TED;
DE   AltName: Full=Transmembrane protein 28;
DE   AltName: Full=Transmembrane protein FAM155B;
GN   Name=Nalf2; Synonyms=Fam155b, Tmem28;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Probable component of the NALCN channel complex, a channel
CC       that regulates the resting membrane potential and controls neuronal
CC       excitability. {ECO:0000250|UniProtKB:O75949}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NALF family. {ECO:0000305}.
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DR   EMBL; BX000691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS41072.1; -.
DR   RefSeq; NP_001074752.1; NM_001081283.1.
DR   AlphaFoldDB; A2BDP1; -.
DR   SMR; A2BDP1; -.
DR   STRING; 10090.ENSMUSP00000094090; -.
DR   GlyGen; A2BDP1; 1 site.
DR   PhosphoSitePlus; A2BDP1; -.
DR   PaxDb; A2BDP1; -.
DR   PRIDE; A2BDP1; -.
DR   ProteomicsDB; 271522; -.
DR   Antibodypedia; 27337; 87 antibodies from 14 providers.
DR   Ensembl; ENSMUST00000096363; ENSMUSP00000094090; ENSMUSG00000071719.
DR   GeneID; 620592; -.
DR   KEGG; mmu:620592; -.
DR   UCSC; uc009tvn.1; mouse.
DR   CTD; 27112; -.
DR   MGI; MGI:3648377; Nalf2.
DR   VEuPathDB; HostDB:ENSMUSG00000071719; -.
DR   eggNOG; ENOG502QQKW; Eukaryota.
DR   GeneTree; ENSGT00940000161362; -.
DR   HOGENOM; CLU_058453_0_0_1; -.
DR   InParanoid; A2BDP1; -.
DR   OMA; GTCGPRY; -.
DR   OrthoDB; 1585247at2759; -.
DR   PhylomeDB; A2BDP1; -.
DR   TreeFam; TF331752; -.
DR   BioGRID-ORCS; 620592; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Fam155a; mouse.
DR   PRO; PR:A2BDP1; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; A2BDP1; protein.
DR   Bgee; ENSMUSG00000071719; Expressed in dentate gyrus of hippocampal formation granule cell and 30 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR   InterPro; IPR029604; NALF1/2.
DR   PANTHER; PTHR15819:SF8; PTHR15819:SF8; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..471
FT                   /note="NALCN channel auxiliary factor 2"
FT                   /id="PRO_0000339376"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          76..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          158..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..107
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..175
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  52389 MW;  284FC83F22298219 CRC64;
     MFRGAWMWPG KDAAALTICC CCCCWAPRQS DKPCADSERA QRWRLSLASL LFFTVLLADH
     LWLCAGARPR ARELSSAMRP PWGAGRERQP VPPRAVLPPP PPSPGEPSAS SGTCGPRYSN
     LTKAAPAAGS GPVCNGVPEP TGLDAACTKL ESLQRLFEPT TPAPPLRPPD SPSRAPEFPS
     AKKNLLKGHF RNFTLSFCDT YTVWDLLLGM DRPDSLDCSL DTLLGDLLAV VASPGSGTWE
     ACSNCIEAYQ RLDRHAQEKY DEFDLVLHKY LQAEEYSIRS CTKGCKAVYK AWLCSEYFSV
     TQQECQNWVP CKQYCLEVQT RCPFILPDNE EMVYGGLPGF ICTGLMDTSP KRPETKCCDV
     QWVSCESEKK KFKDSEPPKT HHQQFHHSYF HHYHHQYHHY HPRHEPPSRV SNKPSLLPVS
     GGSRLSPSRI RLCVLVLILL HTVVSFSSSQ SGGGLGLETL PALEEGLTQE E