ID   NALF2_XENTR             Reviewed;         442 AA.
AC   A4IHZ3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=NALCN channel auxiliary factor 2;
DE   AltName: Full=Transmembrane protein FAM155B;
GN   Name=nalf2; Synonyms=fam155b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of the NALCN channel complex, a channel
CC       that regulates the resting membrane potential and controls neuronal
CC       excitability. {ECO:0000250|UniProtKB:O75949}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NALF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC135763; AAI35764.1; -; mRNA.
DR   RefSeq; NP_001096333.1; NM_001102863.1.
DR   AlphaFoldDB; A4IHZ3; -.
DR   SMR; A4IHZ3; -.
DR   STRING; 8364.ENSXETP00000014379; -.
DR   PaxDb; A4IHZ3; -.
DR   GeneID; 100124919; -.
DR   KEGG; xtr:100124919; -.
DR   CTD; 27112; -.
DR   Xenbase; XB-GENE-952379; nalf2.
DR   eggNOG; ENOG502QQKW; Eukaryota.
DR   InParanoid; A4IHZ3; -.
DR   OMA; GTCGPRY; -.
DR   OrthoDB; 1585247at2759; -.
DR   PhylomeDB; A4IHZ3; -.
DR   TreeFam; TF331752; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000033673; Expressed in brain and 1 other tissue.
DR   ExpressionAtlas; A4IHZ3; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR   InterPro; IPR029604; NALF1/2.
DR   PANTHER; PTHR15819:SF8; PTHR15819:SF8; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..442
FT                   /note="NALCN channel auxiliary factor 2"
FT                   /id="PRO_0000339377"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        279
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        354
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   442 AA;  50210 MW;  85A69545D9004730 CRC64;
     MIRGAWMYPR EDEAVLKICW EPRHSDKPCA DSERAQRWRM SLASLLFFTV LLSNHLWLVS
     AGAKARGSFT FSLQPANSSL LPPQSFPGEG RGCWDTFLSN LTKSAAQPPH CTGVRSTHLD
     TACAKLHYLQ RHRGSFSPSY PQPSSWSSSY WSYPPSSFSS KRNFLKAYFR NYTLSFCDTY
     TILDLLLGMS NPDSLDCSLE SLMEDFVGAA AASPALIEGE VCSSCIQAYQ RLDQHAQEKY
     EEFDFVLEKY LQSGEYSVRS CVGDCKAVYK AWLCSEYFNV TQRQCRHRIP CKQYCLEVQT
     RCPFMLPDND DLIYGGLPGF ICTDMLENHM SNTEAECCDV RWHSCKTQGS GNHNTSTKST
     DSRFKYYPHH QHHRDHHLHP YHHQHHQSLL PVSAGSRLGN TRLRLCVLVL MLLHTMASFS
     VVQNGVTLEP LPGLDDSSSH EE