NALP7_HUMAN
ID NALP7_HUMAN Reviewed; 980 AA.
AC Q8WX94; E9PE16; Q32MH8; Q7RTR1;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 7;
DE AltName: Full=Nucleotide-binding oligomerization domain protein 12;
DE AltName: Full=PYRIN-containing APAF1-like protein 3;
GN Name=NLRP7; Synonyms=NALP7, NOD12, PYPAF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12019269; DOI=10.1074/jbc.m203915200;
RA Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M.,
RA Geddes B.J., Briskin M., DiStefano P.S., Bertin J.;
RT "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates
RT activation of NF-kappa B and caspase-1-dependent cytokine processing.";
RL J. Biol. Chem. 277:29874-29880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12563287; DOI=10.1038/nrm1019;
RA Tschopp J., Martinon F., Burns K.;
RT "NALPs: a novel protein family involved in inflammation.";
RL Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION (ISOFORM 2).
RX PubMed=12766759; DOI=10.1038/nri1086;
RA Inohara N., Nunez G.;
RT "NODs: intracellular proteins involved in inflammation and apoptosis.";
RL Nat. Rev. Immunol. 3:371-382(2003).
RN [6]
RP FUNCTION, INTERACTION WITH CASP1 AND IL1B, AND TISSUE SPECIFICITY.
RX PubMed=15817483; DOI=10.1074/jbc.m410057200;
RA Kinoshita T., Wang Y., Hasegawa M., Imamura R., Suda T.;
RT "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of
RT caspase-1-dependent interleukin-1beta secretion.";
RL J. Biol. Chem. 280:21720-21725(2005).
RN [7]
RP STRUCTURE BY NMR OF 1-96.
RX PubMed=20547486; DOI=10.1074/jbc.m110.113191;
RA Pinheiro A.S., Proell M., Eibl C., Page R., Schwarzenbacher R., Peti W.;
RT "Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-
RT pyrin-mediated effector domain signaling in innate immunity.";
RL J. Biol. Chem. 285:27402-27410(2010).
RN [8]
RP VARIANTS HYDM1 TRP-693; PRO-693 AND SER-913, AND TISSUE SPECIFICITY.
RX PubMed=16462743; DOI=10.1038/ng1740;
RA Murdoch S., Djuric U., Mazhar B., Seoud M., Khan R., Kuick R., Bagga R.,
RA Kircheisen R., Ao A., Ratti B., Hanash S., Rouleau G.A., Slim R.;
RT "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive
RT wastage in humans.";
RL Nat. Genet. 38:300-302(2006).
RN [9]
RP VARIANTS HYDM1 ARG-398; SER-651; TRP-693; PRO-693; GLN-693; ALA-716;
RP TRP-721; TYR-761 AND SER-913.
RX PubMed=19246479; DOI=10.1136/jmg.2008.064196;
RA Wang C.M., Dixon P.H., Decordova S., Hodges M.D., Sebire N.J., Ozalp S.,
RA Fallahian M., Sensi A., Ashrafi F., Repiska V., Zhao J., Xiang Y.,
RA Savage P.M., Seckl M.J., Fisher R.A.;
RT "Identification of 13 novel NLRP7 mutations in 20 families with recurrent
RT hydatidiform mole; missense mutations cluster in the leucine-rich region.";
RL J. Med. Genet. 46:569-575(2009).
RN [10]
RP VARIANTS HYDM1 ARG-310; ILE-311; ILE-319; ASN-379; THR-481; ARG-511;
RP VAL-719 AND THR-799.
RX PubMed=23963444; DOI=10.1093/molehr/gat056;
RA Andreasen L., Christiansen O.B., Niemann I., Bolund L., Sunde L.;
RT "NLRP7 or KHDC3L genes and the etiology of molar pregnancies and recurrent
RT miscarriage.";
RL Mol. Hum. Reprod. 19:773-781(2013).
CC -!- FUNCTION: Inhibits CASP1/caspase-1-dependent IL1B secretion.
CC {ECO:0000269|PubMed:15817483}.
CC -!- SUBUNIT: Directly interacts with CASP1 and IL1B.
CC {ECO:0000269|PubMed:15817483}.
CC -!- INTERACTION:
CC Q8WX94-3; Q8WX94-3: NLRP7; NbExp=7; IntAct=EBI-21978841, EBI-21978841;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WX94-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WX94-2; Sequence=VSP_016906, VSP_016907;
CC Name=3;
CC IsoId=Q8WX94-3; Sequence=VSP_016907;
CC -!- TISSUE SPECIFICITY: Expressed in numerous tissues including uterus and
CC ovary, with low levels in heart and brain. Not detected in skeletal
CC muscle. {ECO:0000269|PubMed:15817483, ECO:0000269|PubMed:16462743}.
CC -!- INDUCTION: By bacterial lipopolysaccharides (LPS) and IL1B/interleukin-
CC 1 beta in peripheral blood mononuclear cells.
CC -!- DISEASE: Hydatidiform mole, recurrent, 1 (HYDM1) [MIM:231090]: A
CC disorder characterized by excessive trophoblast development that
CC produces a growing mass of tissue inside the uterus at the beginning of
CC a pregnancy. It leads to abnormal pregnancies with no embryo, and
CC cystic degeneration of the chorionic villi.
CC {ECO:0000269|PubMed:16462743, ECO:0000269|PubMed:19246479,
CC ECO:0000269|PubMed:23963444}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=INFEVERS; Note=Repertory of FMF and hereditary
CC autoinflammatory disorders mutations;
CC URL="https://infevers.umai-montpellier.fr/web/search.php?n=8";
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DR EMBL; AF464765; AAL69963.1; -; mRNA.
DR EMBL; AY154462; AAO18158.1; -; mRNA.
DR EMBL; AC011476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109125; AAI09126.1; -; mRNA.
DR EMBL; BK001113; DAA01246.1; -; mRNA.
DR CCDS; CCDS12912.1; -. [Q8WX94-2]
DR CCDS; CCDS33109.1; -. [Q8WX94-1]
DR CCDS; CCDS46183.1; -. [Q8WX94-3]
DR RefSeq; NP_001120727.1; NM_001127255.1. [Q8WX94-3]
DR RefSeq; NP_631915.2; NM_139176.3. [Q8WX94-2]
DR RefSeq; NP_996611.2; NM_206828.3. [Q8WX94-1]
DR RefSeq; XP_006723138.1; XM_006723075.3. [Q8WX94-3]
DR RefSeq; XP_006723139.1; XM_006723076.3. [Q8WX94-3]
DR RefSeq; XP_011524901.1; XM_011526599.2. [Q8WX94-3]
DR PDB; 2KM6; NMR; -; A=1-96.
DR PDBsum; 2KM6; -.
DR AlphaFoldDB; Q8WX94; -.
DR BMRB; Q8WX94; -.
DR SMR; Q8WX94; -.
DR BioGRID; 128265; 162.
DR STRING; 9606.ENSP00000467123; -.
DR iPTMnet; Q8WX94; -.
DR PhosphoSitePlus; Q8WX94; -.
DR BioMuta; NLRP7; -.
DR DMDM; 24212128; -.
DR jPOST; Q8WX94; -.
DR MassIVE; Q8WX94; -.
DR MaxQB; Q8WX94; -.
DR PeptideAtlas; Q8WX94; -.
DR PRIDE; Q8WX94; -.
DR ProteomicsDB; 74988; -. [Q8WX94-1]
DR ProteomicsDB; 74989; -. [Q8WX94-2]
DR ProteomicsDB; 74990; -. [Q8WX94-3]
DR Antibodypedia; 46386; 161 antibodies from 28 providers.
DR DNASU; 199713; -.
DR Ensembl; ENST00000328092.9; ENSP00000329568.5; ENSG00000167634.12. [Q8WX94-2]
DR Ensembl; ENST00000340844.6; ENSP00000339491.2; ENSG00000167634.12. [Q8WX94-1]
DR Ensembl; ENST00000588756.5; ENSP00000467123.1; ENSG00000167634.12. [Q8WX94-3]
DR Ensembl; ENST00000590030.5; ENSP00000465520.1; ENSG00000167634.12. [Q8WX94-1]
DR Ensembl; ENST00000592784.5; ENSP00000468706.1; ENSG00000167634.12. [Q8WX94-3]
DR Ensembl; ENST00000610424.4; ENSP00000482887.1; ENSG00000274571.4. [Q8WX94-3]
DR Ensembl; ENST00000610790.1; ENSP00000478726.1; ENSG00000274571.4. [Q8WX94-1]
DR Ensembl; ENST00000610853.4; ENSP00000478890.1; ENSG00000274571.4. [Q8WX94-2]
DR Ensembl; ENST00000610981.4; ENSP00000479459.1; ENSG00000277776.4. [Q8WX94-3]
DR Ensembl; ENST00000611597.4; ENSP00000481117.1; ENSG00000274571.4. [Q8WX94-1]
DR Ensembl; ENST00000613233.1; ENSP00000483203.1; ENSG00000277776.4. [Q8WX94-1]
DR Ensembl; ENST00000614879.1; ENSP00000484444.1; ENSG00000277071.4. [Q8WX94-1]
DR Ensembl; ENST00000615426.4; ENSP00000484426.1; ENSG00000277071.4. [Q8WX94-3]
DR Ensembl; ENST00000615699.1; ENSP00000480449.1; ENSG00000277786.4. [Q8WX94-1]
DR Ensembl; ENST00000618261.1; ENSP00000483353.1; ENSG00000277179.4. [Q8WX94-1]
DR Ensembl; ENST00000618343.4; ENSP00000480226.1; ENSG00000274174.4. [Q8WX94-3]
DR Ensembl; ENST00000618672.4; ENSP00000481452.1; ENSG00000277179.4. [Q8WX94-3]
DR Ensembl; ENST00000618740.4; ENSP00000484808.1; ENSG00000277786.4. [Q8WX94-3]
DR Ensembl; ENST00000618995.1; ENSP00000481809.1; ENSG00000276804.4. [Q8WX94-1]
DR Ensembl; ENST00000620183.1; ENSP00000480034.1; ENSG00000274174.4. [Q8WX94-1]
DR Ensembl; ENST00000620820.4; ENSP00000482551.1; ENSG00000276804.4. [Q8WX94-3]
DR Ensembl; ENST00000621238.4; ENSP00000481395.1; ENSG00000274571.4. [Q8WX94-3]
DR Ensembl; ENST00000621584.1; ENSP00000479541.1; ENSG00000275483.4. [Q8WX94-1]
DR Ensembl; ENST00000622199.4; ENSP00000482194.1; ENSG00000275483.4. [Q8WX94-3]
DR GeneID; 199713; -.
DR KEGG; hsa:199713; -.
DR UCSC; uc002qih.4; human. [Q8WX94-1]
DR CTD; 199713; -.
DR DisGeNET; 199713; -.
DR GeneCards; NLRP7; -.
DR HGNC; HGNC:22947; NLRP7.
DR HPA; ENSG00000167634; Tissue enriched (testis).
DR MalaCards; NLRP7; -.
DR MIM; 231090; phenotype.
DR MIM; 609661; gene.
DR neXtProt; NX_Q8WX94; -.
DR OpenTargets; ENSG00000167634; -.
DR Orphanet; 254688; Complete hydatidiform mole.
DR Orphanet; 254693; Partial hydatidiform mole.
DR PharmGKB; PA162398003; -.
DR VEuPathDB; HostDB:ENSG00000167634; -.
DR eggNOG; ENOG502S92U; Eukaryota.
DR GeneTree; ENSGT00940000164627; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; Q8WX94; -.
DR OMA; CCEIVVS; -.
DR OrthoDB; 155336at2759; -.
DR PhylomeDB; Q8WX94; -.
DR PathwayCommons; Q8WX94; -.
DR SignaLink; Q8WX94; -.
DR BioGRID-ORCS; 199713; 11 hits in 1062 CRISPR screens.
DR EvolutionaryTrace; Q8WX94; -.
DR GeneWiki; NLRP7; -.
DR GenomeRNAi; 199713; -.
DR Pharos; Q8WX94; Tbio.
DR PRO; PR:Q8WX94; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8WX94; protein.
DR Bgee; ENSG00000167634; Expressed in granulocyte and 36 other tissues.
DR ExpressionAtlas; Q8WX94; baseline and differential.
DR Genevisible; Q8WX94; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IDA:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0089720; F:caspase binding; IPI:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0019966; F:interleukin-1 binding; IPI:UniProtKB.
DR GO; GO:0071347; P:cellular response to interleukin-1; IEP:UniProtKB.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB.
DR GO; GO:1905246; P:negative regulation of aspartic-type peptidase activity; IDA:UniProtKB.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IMP:UniProtKB.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IMP:UniProtKB.
DR GO; GO:0010955; P:negative regulation of protein processing; IDA:UniProtKB.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Disease variant;
KW Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..980
FT /note="NACHT, LRR and PYD domains-containing protein 7"
FT /id="PRO_0000080895"
FT DOMAIN 1..93
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 172..491
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 614..638
FT /note="LRR 1"
FT REPEAT 674..697
FT /note="LRR 2"
FT REPEAT 760..784
FT /note="LRR 3"
FT REPEAT 788..810
FT /note="LRR 4"
FT REPEAT 817..840
FT /note="LRR 5"
FT REPEAT 845..868
FT /note="LRR 6"
FT REPEAT 874..897
FT /note="LRR 7"
FT REPEAT 902..928
FT /note="LRR 8"
FT REPEAT 933..957
FT /note="LRR 9"
FT REGION 104..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 178..185
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT VAR_SEQ 644..671
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_016906"
FT VAR_SEQ 938
FT /note="L -> LWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR
FT QRTGSLKILRL (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016907"
FT VARIANT 310
FT /note="Q -> R (in HYDM1; unknown pathological significance;
FT dbSNP:rs77812009)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085072"
FT VARIANT 311
FT /note="L -> I (in HYDM1; unknown pathological significance;
FT dbSNP:rs79513034)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085073"
FT VARIANT 319
FT /note="V -> I (in HYDM1; unknown pathological significance;
FT dbSNP:rs775882)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_026710"
FT VARIANT 379
FT /note="K -> N (in HYDM1; unknown pathological significance;
FT dbSNP:rs10418277)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085074"
FT VARIANT 398
FT /note="L -> R (in HYDM1; dbSNP:rs104895548)"
FT /evidence="ECO:0000269|PubMed:19246479"
FT /id="VAR_059035"
FT VARIANT 481
FT /note="A -> T (in HYDM1; unknown pathological significance;
FT dbSNP:rs61747414)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085075"
FT VARIANT 487
FT /note="G -> E (in dbSNP:rs775881)"
FT /id="VAR_060103"
FT VARIANT 511
FT /note="K -> R (in HYDM1; unknown pathological significance;
FT dbSNP:rs61743949)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085076"
FT VARIANT 651
FT /note="P -> S (in HYDM1; dbSNP:rs104895549)"
FT /evidence="ECO:0000269|PubMed:19246479"
FT /id="VAR_059036"
FT VARIANT 693
FT /note="R -> P (in HYDM1; dbSNP:rs104895502)"
FT /evidence="ECO:0000269|PubMed:16462743,
FT ECO:0000269|PubMed:19246479"
FT /id="VAR_026711"
FT VARIANT 693
FT /note="R -> Q (in HYDM1; dbSNP:rs104895502)"
FT /evidence="ECO:0000269|PubMed:19246479"
FT /id="VAR_059037"
FT VARIANT 693
FT /note="R -> W (in HYDM1; dbSNP:rs104895506)"
FT /evidence="ECO:0000269|PubMed:16462743,
FT ECO:0000269|PubMed:19246479"
FT /id="VAR_026712"
FT VARIANT 716
FT /note="P -> A (in HYDM1; dbSNP:rs104895550)"
FT /evidence="ECO:0000269|PubMed:19246479"
FT /id="VAR_059038"
FT VARIANT 719
FT /note="A -> V (in HYDM1; unknown pathological significance;
FT dbSNP:rs104895526)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085077"
FT VARIANT 721
FT /note="R -> W (in HYDM1; dbSNP:rs104895525)"
FT /evidence="ECO:0000269|PubMed:19246479"
FT /id="VAR_059039"
FT VARIANT 761
FT /note="C -> Y (in HYDM1; dbSNP:rs104895552)"
FT /evidence="ECO:0000269|PubMed:19246479"
FT /id="VAR_059040"
FT VARIANT 799
FT /note="N -> T (in HYDM1; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:23963444"
FT /id="VAR_085078"
FT VARIANT 913
FT /note="N -> S (in HYDM1; dbSNP:rs104895503)"
FT /evidence="ECO:0000269|PubMed:16462743,
FT ECO:0000269|PubMed:19246479"
FT /id="VAR_026713"
FT VARIANT 971
FT /note="T -> A (in dbSNP:rs7256020)"
FT /id="VAR_026714"
FT CONFLICT 310..311
FT /note="QL -> RI (in Ref. 4; AAI09126)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="A -> T (in Ref. 4; AAI09126)"
FT /evidence="ECO:0000305"
FT HELIX 4..16
FT /evidence="ECO:0007829|PDB:2KM6"
FT HELIX 21..29
FT /evidence="ECO:0007829|PDB:2KM6"
FT HELIX 38..40
FT /evidence="ECO:0007829|PDB:2KM6"
FT HELIX 43..48
FT /evidence="ECO:0007829|PDB:2KM6"
FT HELIX 52..61
FT /evidence="ECO:0007829|PDB:2KM6"
FT HELIX 64..77
FT /evidence="ECO:0007829|PDB:2KM6"
FT HELIX 84..87
FT /evidence="ECO:0007829|PDB:2KM6"
FT TURN 88..91
FT /evidence="ECO:0007829|PDB:2KM6"
SQ SEQUENCE 980 AA; 111807 MW; 822AF2FD4338003D CRC64;
MTSPQLEWTL QTLLEQLNED ELKSFKSLLW AFPLEDVLQK TPWSEVEEAD GKKLAEILVN
TSSENWIRNA TVNILEEMNL TELCKMAKAE MMEDGQVQEI DNPELGDAEE DSELAKPGEK
EGWRNSMEKQ SLVWKNTFWQ GDIDNFHDDV TLRNQRFIPF LNPRTPRKLT PYTVVLHGPA
GVGKTTLAKK CMLDWTDCNL SPTLRYAFYL SCKELSRMGP CSFAELISKD WPELQDDIPS
ILAQAQRILF VVDGLDELKV PPGALIQDIC GDWEKKKPVP VLLGSLLKRK MLPRAALLVT
TRPRALRDLQ LLAQQPIYVR VEGFLEEDRR AYFLRHFGDE DQAMRAFELM RSNAALFQLG
SAPAVCWIVC TTLKLQMEKG EDPVPTCLTR TGLFLRFLCS RFPQGAQLRG ALRTLSLLAA
QGLWAQMSVF HREDLERLGV QESDLRLFLD GDILRQDRVS KGCYSFIHLS FQQFLTALFY
ALEKEEGEDR DGHAWDIGDV QKLLSGEERL KNPDLIQVGH FLFGLANEKR AKELEATFGC
RMSPDIKQEL LQCKAHLHAN KPLSVTDLKE VLGCLYESQE EELAKVVVAP FKEISIHLTN
TSEVMHCSFS LKHCQDLQKL SLQVAKGVFL ENYMDFELDI EFERCTYLTI PNWARQDLRS
LRLWTDFCSL FSSNSNLKFL EVKQSFLSDS SVRILCDHVT RSTCHLQKVE IKNVTPDTAY
RDFCLAFIGK KTLTHLTLAG HIEWERTMML MLCDLLRNHK CNLQYLRLGG HCATPEQWAE
FFYVLKANQS LKHLRLSANV LLDEGAMLLY KTMTRPKHFL QMLSLENCRL TEASCKDLAA
VLVVSKKLTH LCLAKNPIGD TGVKFLCEGL SYPDCKLQTL VLQQCSITKL GCRYLSEALQ
EACSLTNLDL SINQIARGLW ILCQALENPN CNLKHLRLKT YETNLEIKKL LEEVKEKNPK
LTIDCNASGA TAPPCCDFFC
