NANC_ECOL6
ID NANC_ECOL6 Reviewed; 238 AA.
AC Q8CVG4;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Probable N-acetylneuraminic acid outer membrane channel protein NanC;
DE Short=Porin NanC;
DE Flags: Precursor;
GN Name=nanC; OrderedLocusNames=c5389;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Outer membrane channel protein allowing the entry of N-
CC acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host
CC cell surfaces) into the bacteria. NanC proteins form high-conductance
CC channels which are open at low membrane potentials and which have a
CC weak anion selectivity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the oligogalacturonate-specific porin KdgM (TC
CC 1.B.35) family. NanC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN83811.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN83811.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001304536.1; NC_004431.1.
DR AlphaFoldDB; Q8CVG4; -.
DR SMR; Q8CVG4; -.
DR STRING; 199310.c5389; -.
DR EnsemblBacteria; AAN83811; AAN83811; c5389.
DR KEGG; ecc:c5389; -.
DR eggNOG; COG1452; Bacteria.
DR HOGENOM; CLU_081853_2_0_6; -.
DR OMA; YFKRNSG; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR009331; Oligogalacturonate-sp_porin.
DR PANTHER; PTHR38105; PTHR38105; 1.
DR Pfam; PF06178; KdgM; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW Sugar transport; Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..238
FT /note="Probable N-acetylneuraminic acid outer membrane
FT channel protein NanC"
FT /id="PRO_0000016603"
FT TOPO_DOM 24
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 25..33
FT /evidence="ECO:0000250"
FT TOPO_DOM 34..37
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 38..48
FT /evidence="ECO:0000250"
FT TOPO_DOM 49..52
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 53..64
FT /evidence="ECO:0000250"
FT TOPO_DOM 65..75
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 76..87
FT /evidence="ECO:0000250"
FT TOPO_DOM 88..91
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 92..102
FT /evidence="ECO:0000250"
FT TOPO_DOM 103..105
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 106..118
FT /evidence="ECO:0000250"
FT TOPO_DOM 119..122
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 123..134
FT /evidence="ECO:0000250"
FT TOPO_DOM 135..149
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 150..160
FT /evidence="ECO:0000250"
FT TOPO_DOM 161..164
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 165..176
FT /evidence="ECO:0000250"
FT TOPO_DOM 177..187
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 188..198
FT /evidence="ECO:0000250"
FT TOPO_DOM 199..203
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 204..212
FT /evidence="ECO:0000250"
FT TOPO_DOM 213..227
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 228..236
FT /evidence="ECO:0000250"
FT TOPO_DOM 237..238
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 238 AA; 27902 MW; 07B99134FEC0D42C CRC64;
MKKAKILSGV LLLCFSSPLI SQAATLDVRG GYRSGSHAYE TRLKVSEGWQ NGWWASMESN
TWNTIHDNKK ENAALNDVQV EVNYAIKLDD QWTVRPGMLT HFSSNGTRYG PYVKLSWDAT
KDLKFGIRYR YDWKAYRQQD LSGDMSRDNV HRWDGYVTYH INSDFTFAWQ TTLYSKQNDY
RYANHKKWAT ENAFVLQYHM TPDITPYIEY DYLDRQGVYN GRDNLSENSY RIGVSFKL
