NANE1_SALTY
ID NANE1_SALTY Reviewed; 226 AA.
AC P60631; Q8XG90;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase 1;
DE EC=5.1.3.9;
DE AltName: Full=ManNAc-6-P epimerase 1;
GN Name=nanE1; OrderedLocusNames=STM1129;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC 6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC ChEBI:CHEBI:57666; EC=5.1.3.9;
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC -!- SIMILARITY: Belongs to the NanE family. {ECO:0000305}.
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DR EMBL; AE006468; AAL20060.1; -; Genomic_DNA.
DR RefSeq; NP_460101.1; NC_003197.2.
DR RefSeq; WP_000054243.1; NC_003197.2.
DR AlphaFoldDB; P60631; -.
DR SMR; P60631; -.
DR STRING; 99287.STM1129; -.
DR PaxDb; P60631; -.
DR EnsemblBacteria; AAL20060; AAL20060; STM1129.
DR GeneID; 1252647; -.
DR KEGG; stm:STM1129; -.
DR PATRIC; fig|99287.12.peg.1196; -.
DR HOGENOM; CLU_086300_0_0_6; -.
DR OMA; QALGFDC; -.
DR PhylomeDB; P60631; -.
DR BioCyc; SENT99287:STM1129-MON; -.
DR UniPathway; UPA00629; UER00682.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0009385; F:N-acylmannosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006053; P:N-acetylmannosamine catabolic process; IBA:GO_Central.
DR GO; GO:0019262; P:N-acetylneuraminate catabolic process; IBA:GO_Central.
DR CDD; cd04729; NanE; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01235; ManNAc6P_epimer; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR007260; NanE.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR36204; PTHR36204; 1.
DR Pfam; PF04131; NanE; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Isomerase; Reference proteome.
FT CHAIN 1..226
FT /note="Putative N-acetylmannosamine-6-phosphate 2-epimerase
FT 1"
FT /id="PRO_0000179794"
SQ SEQUENCE 226 AA; 23973 MW; 547F4985086536CA CRC64;
MSLLARLEQS VHENGGLIVS CQPVPGSPMD KPEIVAAMAQ AAASAGAVAV RIEGIENLRT
VRPHLSVPII GIIKRDLTGS PVRITPYLQD VDALAQAGAD IIAFDASFRS RPVDIDSLLT
RIRLHGLLAM ADCSTVNEGI SCHQKGIEFI GTTLSGYTGP ITPVEPDLAM VTQLSHAGCR
VIAEGRYNTP ALAANAIEHG AWAVTVGSAI TRIEHICQWF SHAVKR
