ID   NANE1_STRPN             Reviewed;         233 AA.
AC   Q97Q95;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase 1;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase 1;
GN   Name=nanE1; OrderedLocusNames=SP_1330;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC       acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC         6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC         ChEBI:CHEBI:57666; EC=5.1.3.9;
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC       fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC   -!- SIMILARITY: Belongs to the NanE family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK75428.1; -; Genomic_DNA.
DR   PIR; C95154; C95154.
DR   RefSeq; WP_000078475.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97Q95; -.
DR   SMR; Q97Q95; -.
DR   STRING; 170187.SP_1330; -.
DR   EnsemblBacteria; AAK75428; AAK75428; SP_1330.
DR   GeneID; 66806463; -.
DR   KEGG; spn:SP_1330; -.
DR   eggNOG; COG3010; Bacteria.
DR   OMA; MIQALNA; -.
DR   PhylomeDB; Q97Q95; -.
DR   BioCyc; SPNE170187:G1FZB-1341-MON; -.
DR   UniPathway; UPA00629; UER00682.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009385; F:N-acylmannosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04729; NanE; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01235; ManNAc6P_epimer; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR007260; NanE.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR36204; PTHR36204; 1.
DR   Pfam; PF04131; NanE; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Isomerase.
FT   CHAIN           1..233
FT                   /note="Putative N-acetylmannosamine-6-phosphate 2-epimerase
FT                   1"
FT                   /id="PRO_0000179805"
SQ   SEQUENCE   233 AA;  25702 MW;  41DC23CDC623437B CRC64;
     MSQIWTKEKF ISQVQGGVIV SCQALPGEAL YNEEFSLMPF MAKAALEAGA VGIRANSVRD
     IKAIQKVVDL PIIGIIKRDY PPQEPYITAT MKEVDELVEC GTTVIAFDAT LRPRYDGLVV
     SEFIKKIKEK YPNQLLMADV SNLDEGLYAF KSGVDFVGTT LSGYTSTSVQ SDEPDFELMK
     KLADFNIPVI AEGKIHYPEQ LKKAYSLGVT SVVIGGAITR PKEIAQRFIN VIK