NANE2_SALTY
ID NANE2_SALTY Reviewed; 229 AA.
AC Q8ZLQ7;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase 2;
DE EC=5.1.3.9;
DE AltName: Full=ManNAc-6-P epimerase 2;
GN Name=nanE2; OrderedLocusNames=STM3337;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC 6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC ChEBI:CHEBI:57666; EC=5.1.3.9;
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC -!- SIMILARITY: Belongs to the NanE family. {ECO:0000305}.
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DR EMBL; AE006468; AAL22206.1; -; Genomic_DNA.
DR RefSeq; NP_462247.1; NC_003197.2.
DR RefSeq; WP_000054441.1; NC_003197.2.
DR PDB; 3IGS; X-ray; 1.50 A; A/B=1-229.
DR PDBsum; 3IGS; -.
DR AlphaFoldDB; Q8ZLQ7; -.
DR SMR; Q8ZLQ7; -.
DR STRING; 99287.STM3337; -.
DR PaxDb; Q8ZLQ7; -.
DR EnsemblBacteria; AAL22206; AAL22206; STM3337.
DR GeneID; 1254860; -.
DR KEGG; stm:STM3337; -.
DR PATRIC; fig|99287.12.peg.3538; -.
DR HOGENOM; CLU_086300_0_0_6; -.
DR OMA; TRPMEIT; -.
DR PhylomeDB; Q8ZLQ7; -.
DR BioCyc; SENT99287:STM3337-MON; -.
DR UniPathway; UPA00629; UER00682.
DR EvolutionaryTrace; Q8ZLQ7; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0009385; F:N-acylmannosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006053; P:N-acetylmannosamine catabolic process; IBA:GO_Central.
DR GO; GO:0019262; P:N-acetylneuraminate catabolic process; IBA:GO_Central.
DR CDD; cd04729; NanE; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01235; ManNAc6P_epimer; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR007260; NanE.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR36204; PTHR36204; 1.
DR Pfam; PF04131; NanE; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Carbohydrate metabolism; Isomerase; Reference proteome.
FT CHAIN 1..229
FT /note="Putative N-acetylmannosamine-6-phosphate 2-epimerase
FT 2"
FT /id="PRO_0000179795"
FT HELIX 3..14
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 17..20
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 32..44
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 48..54
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 55..62
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 69..72
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 88..97
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 100..105
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 115..124
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 128..132
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 136..144
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 148..151
FT /evidence="ECO:0007829|PDB:3IGS"
FT TURN 153..156
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 157..161
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 168..176
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 181..185
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 190..198
FT /evidence="ECO:0007829|PDB:3IGS"
FT STRAND 202..206
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 208..211
FT /evidence="ECO:0007829|PDB:3IGS"
FT HELIX 213..228
FT /evidence="ECO:0007829|PDB:3IGS"
SQ SEQUENCE 229 AA; 24030 MW; 77FC1C3BE0B70719 CRC64;
MSLLEQLDKN IAASGGLIVS CQPVPGSPLD KPEIVAAMAL AAEQAGAVAV RIEGIDNLRM
TRSLVSVPII GIIKRDLDES PVRITPFLDD VDALAQAGAA IIAVDGTARQ RPVAVEALLA
RIHHHHLLAM ADCSSVDDGL ACQRLGADII GTTMSGYTTP DTPEEPDLPL VKALHDAGCR
VIAEGRYNSP ALAAEAIRYG AWAVTVGSAI TRLEHICGWY NDALKKAAS
