ID   NANE2_STRPN             Reviewed;         232 AA.
AC   P65520; Q8DNU6; Q97PE4;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase 2;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase 2;
GN   Name=nanE2; OrderedLocusNames=SP_1685;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC       acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC         6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC         ChEBI:CHEBI:57666; EC=5.1.3.9;
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC       fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC   -!- SIMILARITY: Belongs to the NanE family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK75764.1; -; Genomic_DNA.
DR   PIR; C95196; C95196.
DR   RefSeq; WP_001135651.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P65520; -.
DR   SMR; P65520; -.
DR   STRING; 170187.SP_1685; -.
DR   EnsemblBacteria; AAK75764; AAK75764; SP_1685.
DR   GeneID; 60234421; -.
DR   KEGG; spn:SP_1685; -.
DR   eggNOG; COG3010; Bacteria.
DR   OMA; QALGFDC; -.
DR   PhylomeDB; P65520; -.
DR   BioCyc; SPNE170187:G1FZB-1706-MON; -.
DR   UniPathway; UPA00629; UER00682.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009385; F:N-acylmannosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04729; NanE; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01235; ManNAc6P_epimer; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR007260; NanE.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR36204; PTHR36204; 1.
DR   Pfam; PF04131; NanE; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Isomerase.
FT   CHAIN           1..232
FT                   /note="Putative N-acetylmannosamine-6-phosphate 2-epimerase
FT                   2"
FT                   /id="PRO_0000179806"
SQ   SEQUENCE   232 AA;  25450 MW;  5AC19F57E6E5170A CRC64;
     MPQISKEALI EQIKDGIIVS CQALPHEPLY TEAGGVIPLL VKAAEQGGAV GIRANSVRDI
     KEIKEVTKLP IIGIIKRDYP PQEPFITATM KEVDELAELD IEVIALDCTK RERYDGLEIQ
     EFIRQVKEKY PNQLLMADTS IFEEGLAAVE AGIDFVGTTL SGYTSYSPKV DGPDFELIKK
     LCDAGVDVIA EGKIHTPEQA KQILEYGVRG IVVGGAITRP KEITERFVAS LK