ID   NANE_STRSE              Reviewed;         233 AA.
AC   C5VXY0; Q8RR39; Q8RR48; Q8VVF7; Q8VVG0; Q93HW6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase;
GN   Name=nanE; OrderedLocusNames=SSU1230;
OS   Streptococcus suis (strain P1/7).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=218494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P1/7;
RX   PubMed=19603075; DOI=10.1371/journal.pone.0006072;
RA   Holden M.T.G., Hauser H., Sanders M., Ngo T.H., Cherevach I., Cronin A.,
RA   Goodhead I., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S.,
RA   Croucher N.J., Chieu T.B., Mai N.T.H., Diep T.S., Chinh N.T., Kehoe M.,
RA   Leigh J.A., Ward P.N., Dowson C.G., Whatmore A.M., Chanter N., Iversen P.,
RA   Gottschalk M., Slater J.D., Smith H.E., Spratt B.G., Xu J., Ye C.,
RA   Bentley S., Barrell B.G., Schultsz C., Maskell D.J., Parkhill J.;
RT   "Rapid evolution of virulence and drug resistance in the emerging zoonotic
RT   pathogen Streptococcus suis.";
RL   PLoS ONE 4:E6072-E6072(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144.
RX   PubMed=11705935; DOI=10.1128/iai.69.12.7572-7582.2001;
RA   King S.J., Heath O.J., Luque I., Tarradas C., Dowson C., Whatmore A.M.;
RT   "Distribution and genetic diversity of suilysin in Streptococcus suis
RT   isolated from different diseases of pigs and characterization of the
RT   genetic basis of suilysin absence.";
RL   Infect. Immun. 69:7572-7582(2001).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC       acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC         6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC         ChEBI:CHEBI:57666; EC=5.1.3.9;
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC       fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC   -!- SIMILARITY: Belongs to the NanE family. {ECO:0000305}.
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DR   EMBL; AM946016; CAR46564.1; -; Genomic_DNA.
DR   EMBL; AJ416310; CAC94860.1; -; Genomic_DNA.
DR   RefSeq; WP_012027343.1; NC_012925.1.
DR   AlphaFoldDB; C5VXY0; -.
DR   SMR; C5VXY0; -.
DR   GeneID; 8153634; -.
DR   KEGG; ssi:SSU1230; -.
DR   HOGENOM; CLU_086300_1_0_9; -.
DR   OMA; QALGFDC; -.
DR   UniPathway; UPA00629; UER00682.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009385; F:N-acylmannosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04729; NanE; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01235; ManNAc6P_epimer; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR007260; NanE.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR36204; PTHR36204; 1.
DR   Pfam; PF04131; NanE; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Isomerase.
FT   CHAIN           1..233
FT                   /note="Putative N-acetylmannosamine-6-phosphate 2-
FT                   epimerase"
FT                   /id="PRO_0000387984"
FT   CONFLICT        127
FT                   /note="K -> Q (in Ref. 2; CAC94860)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   233 AA;  25704 MW;  F939BC7AFDF2D7C2 CRC64;
     MGTISKTDLK QQIKDGIIVS CQALPGEPLY REEGGIMPLL VKAAQEAGAV GIRANSVRDI
     KEIKEVTTLP IIGIIKRDYP PQEPFITATM REVDELAALD IEVIALDCTK RERYDGLDIV
     DFIKQIKEKY PEQLFMADIS TFEEGLTAYE AGIDFIGTTL SGYTSYSRQE EGPDIELVDR
     LCRAGIDVIA EGKIHYPDQV KIIHDLGVAG IVVGGAITRP KEIAERFISA LHK