ID   NANE_STRSU              Reviewed;         233 AA.
AC   P0CB52; Q8RR39; Q8RR48; Q8VVF7; Q8VVG0; Q93HW6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase {ECO:0000255|HAMAP-Rule:MF_01235};
DE            EC=5.1.3.9 {ECO:0000255|HAMAP-Rule:MF_01235};
DE   AltName: Full=ManNAc-6-P epimerase {ECO:0000255|HAMAP-Rule:MF_01235};
GN   Name=nanE {ECO:0000255|HAMAP-Rule:MF_01235};
OS   Streptococcus suis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DAT2;
RX   PubMed=11591139; DOI=10.1006/plas.2001.1532;
RA   Takamatsu D., Osaki M., Sekizaki T.;
RT   "Thermosensitive suicide vectors for gene replacement in Streptococcus
RT   suis.";
RL   Plasmid 46:140-148(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=10581 / Serotype 13, and DAT1 / Serotype 2;
RX   PubMed=11889115; DOI=10.1128/jb.184.7.2050-2057.2002;
RA   Takamatsu D., Osaki M., Sekizaki T.;
RT   "Evidence for lateral transfer of the suilysin gene region of Streptococcus
RT   suis.";
RL   J. Bacteriol. 184:2050-2057(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-145.
RC   STRAIN=DH5;
RX   PubMed=11705935; DOI=10.1128/iai.69.12.7572-7582.2001;
RA   King S.J., Heath O.J., Luque I., Tarradas C., Dowson C., Whatmore A.M.;
RT   "Distribution and genetic diversity of suilysin in Streptococcus suis
RT   isolated from different diseases of pigs and characterization of the
RT   genetic basis of suilysin absence.";
RL   Infect. Immun. 69:7572-7582(2001).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC       acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO:0000255|HAMAP-
CC       Rule:MF_01235}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC         6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC         ChEBI:CHEBI:57666; EC=5.1.3.9; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01235};
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC       fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC       {ECO:0000255|HAMAP-Rule:MF_01235}.
CC   -!- SIMILARITY: Belongs to the NanE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01235}.
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DR   EMBL; AB055649; BAB64878.1; -; Genomic_DNA.
DR   EMBL; AB071359; BAB85961.1; -; Genomic_DNA.
DR   EMBL; AB071365; BAB85973.1; -; Genomic_DNA.
DR   EMBL; AJ416308; CAC94856.1; -; Genomic_DNA.
DR   RefSeq; WP_009910312.1; NZ_VKJM01000008.1.
DR   RefSeq; WP_012027343.1; NZ_WODB01000004.1.
DR   AlphaFoldDB; P0CB52; -.
DR   SMR; P0CB52; -.
DR   STRING; 996306.SSUR61_2091; -.
DR   GeneID; 8153634; -.
DR   OrthoDB; 1710586at2; -.
DR   UniPathway; UPA00629; UER00682.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009385; F:N-acylmannosamine-6-phosphate 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04729; NanE; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01235; ManNAc6P_epimer; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR007260; NanE.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR36204; PTHR36204; 1.
DR   Pfam; PF04131; NanE; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Isomerase.
FT   CHAIN           1..233
FT                   /note="Putative N-acetylmannosamine-6-phosphate 2-
FT                   epimerase"
FT                   /id="PRO_0000179813"
FT   VARIANT         3
FT                   /note="K -> T (in strain: DAT2)"
FT   VARIANT         7..8
FT                   /note="EA -> TD (in strain: DAT2)"
FT   VARIANT         8
FT                   /note="A -> V (in strain: 10581)"
FT   VARIANT         11
FT                   /note="E -> Q (in strain: DAT2)"
FT   VARIANT         19
FT                   /note="I -> V (in strain: DAT2)"
FT   VARIANT         124
FT                   /note="N -> K (in strain: DAT2 and 10581)"
FT   VARIANT         205
FT                   /note="D -> N (in strain: 10581)"
SQ   SEQUENCE   233 AA;  25716 MW;  8BFFAC6D8D2EA088 CRC64;
     MGKISKEALK EQIKDGIIIS CQALPGEPLY REEGGIMPLL VKAAQEAGAV GIRANSVRDI
     KEIKEVTTLP IIGIIKRDYP PQEPFITATM REVDELAALD IEVIALDCTK RERYDGLDIV
     DFINQIKEKY PEQLFMADIS TFEEGLTAYE AGIDFIGTTL SGYTSYSRQE EGPDIELVDR
     LCRAGIDVIA EGKIHYPDQV KIIHDLGVAG IVVGGAITRP KEIAERFISA LHK