NANG2_HUMAN
ID NANG2_HUMAN Reviewed; 232 AA.
AC Q8N7R0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Putative homeobox protein NANOG2;
GN Name=NANOGP1; Synonyms=NANOG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryonic stem cell;
RX PubMed=15108323; DOI=10.1002/dvdy.20034;
RA Hart A.H., Hartley L., Ibrahim M., Robb L.;
RT "Identification, cloning and expression analysis of the pluripotency
RT promoting Nanog genes in mouse and human.";
RL Dev. Dyn. 230:187-198(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP GENE FAMILY.
RX PubMed=15233988; DOI=10.1016/j.ygeno.2004.02.014;
RA Booth H.A., Holland P.W.;
RT "Eleven daughters of NANOG.";
RL Genomics 84:229-238(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=16469101; DOI=10.1186/1471-2148-6-12;
RA Fairbanks D.J., Maughan P.J.;
RT "Evolution of the NANOG pseudogene family in the human and chimpanzee
RT genomes.";
RL BMC Evol. Biol. 6:12-12(2006).
CC -!- FUNCTION: Probable transcriptional regulator.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryonic stem cells (ES).
CC {ECO:0000269|PubMed:15108323}.
CC -!- SIMILARITY: Belongs to the Nanog homeobox family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. According to
CC PubMed:15233988. {ECO:0000305}.
CC -!- CAUTION: Exists an other tandem duplicated gene (NANOG) and 10 other
CC NANOG-related nucleotide sequences located on different chromosomes,
CC all of which are processed pseudogenes lacking introns (NANOGP2 to
CC NANOGP11); except NANOGP8 which is a retrogene. {ECO:0000305}.
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DR EMBL; AY455283; AAS57555.1; -; mRNA.
DR EMBL; AK097770; BAC05167.1; -; mRNA.
DR AlphaFoldDB; Q8N7R0; -.
DR SMR; Q8N7R0; -.
DR BioMuta; HGNC:23099; -.
DR DMDM; 74762537; -.
DR EPD; Q8N7R0; -.
DR jPOST; Q8N7R0; -.
DR PaxDb; Q8N7R0; -.
DR PeptideAtlas; Q8N7R0; -.
DR PRIDE; Q8N7R0; -.
DR GeneCards; NANOGP1; -.
DR HGNC; HGNC:23099; NANOGP1.
DR neXtProt; NX_Q8N7R0; -.
DR InParanoid; Q8N7R0; -.
DR PhylomeDB; Q8N7R0; -.
DR Pharos; Q8N7R0; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8N7R0; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 5: Uncertain;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..232
FT /note="Putative homeobox protein NANOG2"
FT /id="PRO_0000261423"
FT REPEAT 123..127
FT /note="1"
FT REPEAT 128..132
FT /note="2"
FT REPEAT 133..137
FT /note="3"
FT REPEAT 143..147
FT /note="4"
FT REPEAT 148..152
FT /note="5"
FT REPEAT 153..157
FT /note="6"
FT REPEAT 158..162
FT /note="7"
FT REPEAT 163..167
FT /note="8"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..167
FT /note="8 X repeats starting with a Trp in each unit"
FT REGION 123..167
FT /note="Sufficient for transactivation activity"
FT /evidence="ECO:0000250"
FT REGION 168..232
FT /note="Sufficient for strong transactivation activity"
FT /evidence="ECO:0000250"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 232 AA; 26880 MW; 5C525D1B54F291BA CRC64;
MDLPIQDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL CVLNDRFQRQ
KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN WLKNSNGVTQ GCLVNPTGNL
PMWSNQTWNN STWSNQTQNI QSWSNHSWNT QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ
FQPNSPASDL QAALEAAGEG LNVIQQTTRY FNTPQTMDLF LNYSMNMQPE DV
