ID   NANG2_PANTR             Reviewed;         232 AA.
AC   A2T763;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative homeobox protein NANOG2;
GN   Name=NANOGP1; Synonyms=NANOG2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional regulator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Nanog homeobox family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; DQ977380; ABM92018.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2T763; -.
DR   SMR; A2T763; -.
DR   InParanoid; A2T763; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   5: Uncertain;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..232
FT                   /note="Putative homeobox protein NANOG2"
FT                   /id="PRO_0000285527"
FT   REPEAT          123..127
FT                   /note="1"
FT   REPEAT          128..132
FT                   /note="2"
FT   REPEAT          133..137
FT                   /note="3"
FT   REPEAT          143..147
FT                   /note="4"
FT   REPEAT          148..152
FT                   /note="5"
FT   REPEAT          153..157
FT                   /note="6"
FT   REPEAT          158..162
FT                   /note="7"
FT   REPEAT          163..167
FT                   /note="8"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..167
FT                   /note="8 X repeats starting with a Trp in each unit"
FT   REGION          123..167
FT                   /note="Sufficient for transactivation activity"
FT                   /evidence="ECO:0000250"
FT   REGION          168..232
FT                   /note="Sufficient for strong transactivation activity"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        23..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  26808 MW;  B8579DEF05535952 CRC64;
     MDLPIEDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL CVLNDRFQRQ
     KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN WLKNSNGVTQ GCLVNPTGNL
     PMWSNQTWNN SIWSNETQNI QSWSNHSWNT QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ
     FQPNSPASDL EAALEAAGEG LNVIQQTARY FSTPQTMDLF LNYSTNMQPE DV