NANGN_HUMAN
ID NANGN_HUMAN Reviewed; 188 AA.
AC Q7Z5D8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=NANOG neighbor homeobox;
DE AltName: Full=Homeobox protein C14;
GN Name=NANOGNB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RA Guo J.H., Yu L.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-188.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; AY151139; AAP76323.1; -; mRNA.
DR EMBL; BC036226; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44826.1; -.
DR RefSeq; NP_001138937.1; NM_001145465.1.
DR AlphaFoldDB; Q7Z5D8; -.
DR SMR; Q7Z5D8; -.
DR BioGRID; 131826; 2.
DR IntAct; Q7Z5D8; 1.
DR STRING; 9606.ENSP00000371553; -.
DR iPTMnet; Q7Z5D8; -.
DR PhosphoSitePlus; Q7Z5D8; -.
DR BioMuta; NANOGNB; -.
DR DMDM; 74759191; -.
DR MassIVE; Q7Z5D8; -.
DR PaxDb; Q7Z5D8; -.
DR PeptideAtlas; Q7Z5D8; -.
DR PRIDE; Q7Z5D8; -.
DR Antibodypedia; 70783; 4 antibodies from 4 providers.
DR DNASU; 360030; -.
DR Ensembl; ENST00000382119.1; ENSP00000371553.1; ENSG00000205857.2.
DR GeneID; 360030; -.
DR KEGG; hsa:360030; -.
DR MANE-Select; ENST00000382119.1; ENSP00000371553.1; NM_001145465.1; NP_001138937.1.
DR UCSC; uc009zfx.2; human.
DR CTD; 360030; -.
DR GeneCards; NANOGNB; -.
DR HGNC; HGNC:24958; NANOGNB.
DR HPA; ENSG00000205857; Not detected.
DR neXtProt; NX_Q7Z5D8; -.
DR PharmGKB; PA165513123; -.
DR VEuPathDB; HostDB:ENSG00000205857; -.
DR eggNOG; ENOG502RU3B; Eukaryota.
DR GeneTree; ENSGT00400000025247; -.
DR HOGENOM; CLU_143203_0_0_1; -.
DR InParanoid; Q7Z5D8; -.
DR OMA; SRCPTIQ; -.
DR OrthoDB; 1479609at2759; -.
DR PhylomeDB; Q7Z5D8; -.
DR TreeFam; TF350480; -.
DR PathwayCommons; Q7Z5D8; -.
DR SignaLink; Q7Z5D8; -.
DR BioGRID-ORCS; 360030; 22 hits in 1068 CRISPR screens.
DR ChiTaRS; NANOGNB; human.
DR GenomeRNAi; 360030; -.
DR Pharos; Q7Z5D8; Tdark.
DR PRO; PR:Q7Z5D8; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q7Z5D8; protein.
DR Bgee; ENSG00000205857; Expressed in lower esophagus mucosa and 8 other tissues.
DR ExpressionAtlas; Q7Z5D8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..188
FT /note="NANOG neighbor homeobox"
FT /id="PRO_0000341417"
FT DNA_BIND 102..161
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 28..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 22750 MW; 8C907E0B232146F5 CRC64;
MHRARWLTPV IPALWEAEAG RSRGQEIETI LANKKQSAMP WDQDPEQSTG NYSEDEQNGK
QKWREEGEAG RKREREKEEK NEKELQDEQE NKRKRENEKQ KQYPEKRLVS KSLMHTLWAK
FKLNRCPTIQ ESLSLSFEFD MTHKQISQWF CKTRKKYNKE MSKRKHKKKH MRWRSLCCQG
WSRTPALK
