NANOG_PANTR
ID NANOG_PANTR Reviewed; 305 AA.
AC Q3LTE0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Homeobox protein NANOG;
DE AltName: Full=Homeobox transcription factor Nanog;
GN Name=NANOG;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND GENE FAMILY.
RX PubMed=16469101; DOI=10.1186/1471-2148-6-12;
RA Fairbanks D.J., Maughan P.J.;
RT "Evolution of the NANOG pseudogene family in the human and chimpanzee
RT genomes.";
RL BMC Evol. Biol. 6:12-12(2006).
CC -!- FUNCTION: Transcription regulator involved in inner cell mass and
CC embryonic stem (ES) cells proliferation and self-renewal. Imposes
CC pluripotency on ES cells and prevents their differentiation towards
CC extraembryonic endoderm and trophectoderm lineages. Blocks bone
CC morphogenetic protein-induced mesoderm differentiation of ES cells by
CC physically interacting with SMAD1 and interfering with the recruitment
CC of coactivators to the active SMAD transcriptional complexes. Acts as a
CC transcriptional activator or repressor. Binds optimally to the DNA
CC consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-
CC 3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its
CC expression in differentiating (ES) cells: binds to its own promoter
CC following interaction with ZNF281/ZFP281, leading to recruitment of the
CC NuRD complex and subsequent repression of expression. When
CC overexpressed, promotes cells to enter into S phase and proliferation
CC (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q80Z64,
CC ECO:0000250|UniProtKB:Q9H9S0}.
CC -!- SUBUNIT: Interacts with SMAD1. Interacts with SALL4. Interacts with
CC ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (By similarity).
CC Interacts with ESRRB; reciprocally modulates their transcriptional
CC activities. Interacts with NSD2 (By similarity).
CC {ECO:0000250|UniProtKB:Q80Z64, ECO:0000250|UniProtKB:Q9H9S0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- MISCELLANEOUS: Exists an other tandem duplicated non-processed
CC pseudogene (NANOGP1) and 9 other NANOG-related nucleotide sequences
CC located on different chromosomes, all of which are processed
CC pseudogenes lacking introns (NANOGP1 to NANOGP11); except NANOGP8 which
CC is absent from the chimpanzee genome.
CC -!- SIMILARITY: Belongs to the Nanog homeobox family. {ECO:0000305}.
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DR EMBL; DQ179631; ABA27089.1; -; Genomic_DNA.
DR RefSeq; NP_001065295.1; NM_001071827.1.
DR AlphaFoldDB; Q3LTE0; -.
DR BMRB; Q3LTE0; -.
DR SMR; Q3LTE0; -.
DR STRING; 9598.ENSPTRP00000007892; -.
DR PaxDb; Q3LTE0; -.
DR Ensembl; ENSPTRT00000008541; ENSPTRP00000007892; ENSPTRG00000029807.
DR GeneID; 748301; -.
DR KEGG; ptr:748301; -.
DR CTD; 79923; -.
DR eggNOG; KOG0491; Eukaryota.
DR GeneTree; ENSGT00670000098076; -.
DR HOGENOM; CLU_086240_0_0_1; -.
DR InParanoid; Q3LTE0; -.
DR OMA; AWSNHSW; -.
DR OrthoDB; 1141558at2759; -.
DR TreeFam; TF337402; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000029807; Expressed in cerebellar cortex and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0019827; P:stem cell population maintenance; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..305
FT /note="Homeobox protein NANOG"
FT /id="PRO_0000261422"
FT REPEAT 196..200
FT /note="1"
FT REPEAT 201..205
FT /note="2"
FT REPEAT 206..210
FT /note="3"
FT REPEAT 216..220
FT /note="4"
FT REPEAT 221..225
FT /note="5"
FT REPEAT 226..230
FT /note="6"
FT REPEAT 231..235
FT /note="7"
FT REPEAT 236..240
FT /note="8"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..151
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q9H9S0"
FT REGION 196..240
FT /note="8 X repeats starting with a Trp in each unit"
FT REGION 196..240
FT /note="Sufficient for transactivation activity"
FT /evidence="ECO:0000250"
FT REGION 241..305
FT /note="Sufficient for strong transactivation activity"
FT /evidence="ECO:0000250"
FT COMPBIAS 35..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 305 AA; 34607 MW; 839441E7C716E7DE CRC64;
MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL
LIQDSPDSST SPKGKQPTSA ENSVTKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL
SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS
YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF
YNCGEESLQS CMQFQPNSPA SDLEAALEAA GEGLNVIQQT ARYFSTPQTM DLFLNYSTNM
QPEDM
