ID   NANR_CITRI              Reviewed;         260 AA.
AC   D2TP58;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN   Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=ROD_45961;
OS   Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=637910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC168;
RX   PubMed=19897651; DOI=10.1128/jb.01144-09;
RA   Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA   Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA   Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT   "The Citrobacter rodentium genome sequence reveals convergent evolution
RT   with human pathogenic Escherichia coli.";
RL   J. Bacteriol. 192:525-538(2010).
CC   -!- FUNCTION: Transcriptional repressor that controls expression of the
CC       genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
CC   -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
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DR   EMBL; FN543502; CBG91291.1; -; Genomic_DNA.
DR   RefSeq; WP_012908490.1; NC_013716.1.
DR   AlphaFoldDB; D2TP58; -.
DR   SMR; D2TP58; -.
DR   STRING; 637910.ROD_45961; -.
DR   KEGG; cro:ROD_45961; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_1_6; -.
DR   OMA; HDAFVDW; -.
DR   OrthoDB; 1875458at2; -.
DR   Proteomes; UP000001889; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_01236; HTH_NanR; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR023730; Tscrpt_reg_NanR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..260
FT                   /note="HTH-type transcriptional repressor NanR"
FT                   /id="PRO_0000415296"
FT   DOMAIN          27..95
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   DNA_BIND        55..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
SQ   SEQUENCE   260 AA;  29212 MW;  48AF5E2237A243BA CRC64;
     MKTFDSQAEN SPAVIGRSLR NRPLARKKLS EMVEEELEQM IRRKEFGEGE QLPSERELMA
     FFNVGRPSVR EALAALKRKG LVQINNGERA RVSRPSADTI IGELSGMAKD FLAHPGGIAH
     FEQLRLFFES SLVRYAAENA TDAQIDLLAK ALEINSQSLD DNALFIRSDV DFHRVLAEIP
     GNPIFKAIHV ALLDWLIAAR PTVPDRELYE HNSVSYQQHI AIVDAIRQRD PDAADRALQT
     HLNSVSATWH ALGQQSKRKK