NANR_ECOL6
ID NANR_ECOL6 Reviewed; 263 AA.
AC Q8FD57;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=c3980;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Transcriptional repressor that controls expression of the
CC genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
CC -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
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DR EMBL; AE014075; AAN82420.1; -; Genomic_DNA.
DR RefSeq; WP_000074795.1; NC_004431.1.
DR AlphaFoldDB; Q8FD57; -.
DR SMR; Q8FD57; -.
DR STRING; 199310.c3980; -.
DR EnsemblBacteria; AAN82420; AAN82420; c3980.
DR KEGG; ecc:c3980; -.
DR eggNOG; COG2186; Bacteria.
DR HOGENOM; CLU_017584_9_1_6; -.
DR OMA; HDAFVDW; -.
DR BioCyc; ECOL199310:C3980-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR HAMAP; MF_01236; HTH_NanR; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR023730; Tscrpt_reg_NanR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..263
FT /note="HTH-type transcriptional repressor NanR"
FT /id="PRO_0000050656"
FT DOMAIN 30..98
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT DNA_BIND 58..77
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 29536 MW; 63B2EB377A2AD762 CRC64;
MSPMNAFDPQ AEDSTTTIGR NLRSRPLARK KLSEMVEEEL EQMIRRREFG EGEQLPSERE
LMAFFNVGRP SVREALAALK RKGLVQINNG ERARVSRPSA DTIIGELSGM AKDFLSHPGG
IAHFEQLRLF FESSLVRYAA EHATDEQIDL LAKALEINSQ SLDNNAAFIR SDVDFHRVLA
EIPGNPIFMA IHVALLDWLI AARPTVADQA LHEHNNVSYQ QHIAIVDAIR RHDPDEADRA
LQSHLNSVSA TWHAFGQTTN KKK
