ID   NANR_ECOLC              Reviewed;         263 AA.
AC   B1IQQ3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN   Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=EcolC_0480;
OS   Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 /
OS   WDCM 00012 / Crooks).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=481805;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Ingram L., Richardson P.;
RT   "Complete sequence of Escherichia coli C str. ATCC 8739.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that controls expression of the
CC       genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
CC   -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
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DR   EMBL; CP000946; ACA76157.1; -; Genomic_DNA.
DR   RefSeq; WP_000523845.1; NZ_CP022959.1.
DR   AlphaFoldDB; B1IQQ3; -.
DR   SMR; B1IQQ3; -.
DR   GeneID; 66672878; -.
DR   KEGG; ecl:EcolC_0480; -.
DR   HOGENOM; CLU_017584_9_1_6; -.
DR   OMA; HDAFVDW; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_01236; HTH_NanR; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR023730; Tscrpt_reg_NanR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..263
FT                   /note="HTH-type transcriptional repressor NanR"
FT                   /id="PRO_1000085734"
FT   DOMAIN          30..98
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   DNA_BIND        58..77
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  29524 MW;  306B3D8FAD7D8BB6 CRC64;
     MGLMNAFDSQ TEDSSPAIGR NLRSRPLARK KLSEMVEEEL EQMIRRREFG EGEQLPSERE
     LMAFFNVGRP SVREALAALK RKGLVQINNG ERARVSRPSA DTIIGELSGM AKDFLSHPGG
     IAHFEQLRLF FESSLVRYAA EHATDEQIDL LAKALEINSQ SLDNNAAFIR SDVDFHRVLA
     EIPGNPIFMA IHVALLDWLI AARPTVTDQA LHEHNNVSYQ QHIAIVDAIR RHDPDEADRA
     LQSHLNSVSA TWHAFGQTTN KKK