NANR_ECOLU
ID NANR_ECOLU Reviewed; 263 AA.
AC B7NDK4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=ECUMN_3700;
OS Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585056;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMN026 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Transcriptional repressor that controls expression of the
CC genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
CC -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
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DR EMBL; CU928163; CAR14854.1; -; Genomic_DNA.
DR RefSeq; WP_000523843.1; NC_011751.1.
DR RefSeq; YP_002414359.1; NC_011751.1.
DR AlphaFoldDB; B7NDK4; -.
DR SMR; B7NDK4; -.
DR STRING; 585056.ECUMN_3700; -.
DR EnsemblBacteria; CAR14854; CAR14854; ECUMN_3700.
DR KEGG; eum:ECUMN_3700; -.
DR PATRIC; fig|585056.7.peg.3882; -.
DR HOGENOM; CLU_017584_9_1_6; -.
DR OMA; HDAFVDW; -.
DR Proteomes; UP000007097; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR HAMAP; MF_01236; HTH_NanR; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR023730; Tscrpt_reg_NanR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..263
FT /note="HTH-type transcriptional repressor NanR"
FT /id="PRO_1000139723"
FT DOMAIN 30..98
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT DNA_BIND 58..77
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 29480 MW; 257E3D9AB8799BB6 CRC64;
MGLMNAFDSQ TEDSSPAIGR NLRSRPLARK KLSEMVEEEL EQMIRRREFG EGEQLPSERE
LMAFFNVGRP SVREALAALK RKGLVQINNG ERARVSRPSA DTIIGELSGM AKDFLSHPGG
IAHFEQLRLF FESSLVRYAA EHATDEQIDL LAKALEINSQ SLDNNAAFIR SDVDFHRVLA
EIPGNPIFMA IHVALLDWLI AARPTVADQA LHEHNNVSYQ QHIAIVDAIR RHDPDEADRA
LQSHLNSVSA TWHAFGQSTN KKK