ID   NANR_KLEAK              Reviewed;         260 AA.
AC   G0E1Z6;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN   Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=EAE_03260;
OS   Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235
OS   / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)
OS   (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=1028307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC
RC   13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56;
RX   PubMed=22493190; DOI=10.1128/jb.00028-12;
RA   Shin S.H., Kim S., Kim J.Y., Lee S., Um Y., Oh M.K., Kim Y.R., Lee J.,
RA   Yang K.S.;
RT   "Complete genome sequence of Enterobacter aerogenes KCTC 2190.";
RL   J. Bacteriol. 194:2373-2374(2012).
CC   -!- FUNCTION: Transcriptional repressor that controls expression of the
CC       genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
CC   -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
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DR   EMBL; CP002824; AEG95587.1; -; Genomic_DNA.
DR   RefSeq; WP_015369707.1; NC_015663.1.
DR   RefSeq; YP_004590866.1; NC_015663.1.
DR   AlphaFoldDB; G0E1Z6; -.
DR   SMR; G0E1Z6; -.
DR   STRING; 1028307.EAE_03260; -.
DR   EnsemblBacteria; AEG95587; AEG95587; EAE_03260.
DR   KEGG; eae:EAE_03260; -.
DR   PATRIC; fig|1028307.3.peg.647; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_1_6; -.
DR   OMA; HDAFVDW; -.
DR   Proteomes; UP000008881; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_01236; HTH_NanR; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR023730; Tscrpt_reg_NanR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="HTH-type transcriptional repressor NanR"
FT                   /id="PRO_0000415299"
FT   DOMAIN          27..95
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   DNA_BIND        55..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  29095 MW;  878CDD718079ADC3 CRC64;
     MSAFDHSSDD TQETIGNSLR RRPLARKKLS EMVEEELEQM IRRGEFGEGG QLPSERELMA
     FFNVGRPSVR EALAALKRKG LVQINNGERA RVSRPSADTI ISELSGLAKD FLSAPGGIAH
     FEQLRLFFES SLVRYAAENA TDEQISLLSK ALEINGQSLD DNAQFIRSDV DFHRVLAEIP
     GNPIFMATHV ALLDWLIAAR PKVSEQELHH HNNVSFQEHI AIFNAIRDRD PDEADRALQT
     HLKSVSATWR ALGKSKKSAK