ID   NANR_SALNS              Reviewed;         260 AA.
AC   B4T751;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN   Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN   OrderedLocusNames=SNSL254_A3603;
OS   Salmonella newport (strain SL254).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=423368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL254;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Transcriptional repressor that controls expression of the
CC       genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
CC   -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01236}.
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DR   EMBL; CP001113; ACF62709.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4T751; -.
DR   SMR; B4T751; -.
DR   EnsemblBacteria; ACF62709; ACF62709; SNSL254_A3603.
DR   KEGG; see:SNSL254_A3603; -.
DR   HOGENOM; CLU_017584_9_1_6; -.
DR   OMA; HDAFVDW; -.
DR   Proteomes; UP000008824; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_01236; HTH_NanR; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR023730; Tscrpt_reg_NanR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="HTH-type transcriptional repressor NanR"
FT                   /id="PRO_0000415302"
FT   DOMAIN          27..95
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   DNA_BIND        55..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  29427 MW;  BEB5213155C0C1C0 CRC64;
     MNAFDSQAED SPTSLGRSLR RRPLARKKLS EMVEEELEQM IRRHEFGEGE QLPSERELMA
     FFNVGRPSVR EALAALKRKG LVQINNGERA RVSRPSADTI ISELSGMAKD FLTHPGGIAH
     FEQLRLFFES SLVRYAAEHA TDEQIALLAK ALEINSQSLD DNALFIRSDV EFHRVLAEIP
     GNPIFMAIHV ALLDWLIAAR PSVPDRELHE HNNVSYQQHI VIVDAIRQRD PDKADRALQT
     HLNSVSATWH ALGKKSQKMR