NANR_SALTY
ID NANR_SALTY Reviewed; 263 AA.
AC P67735; Q8XFH8;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=STM3340;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Transcriptional repressor that controls expression of the
CC genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
CC -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
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DR EMBL; AE006468; AAL22209.1; -; Genomic_DNA.
DR RefSeq; NP_462250.1; NC_003197.2.
DR RefSeq; WP_000382926.1; NC_003197.2.
DR AlphaFoldDB; P67735; -.
DR SMR; P67735; -.
DR STRING; 99287.STM3340; -.
DR PaxDb; P67735; -.
DR EnsemblBacteria; AAL22209; AAL22209; STM3340.
DR GeneID; 1254863; -.
DR KEGG; stm:STM3340; -.
DR PATRIC; fig|99287.12.peg.3541; -.
DR HOGENOM; CLU_017584_9_1_6; -.
DR OMA; HDAFVDW; -.
DR PhylomeDB; P67735; -.
DR BioCyc; SENT99287:STM3340-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR HAMAP; MF_01236; HTH_NanR; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR023730; Tscrpt_reg_NanR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..263
FT /note="HTH-type transcriptional repressor NanR"
FT /id="PRO_0000050659"
FT DOMAIN 30..98
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT DNA_BIND 58..77
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 29803 MW; A41EC57978D122E0 CRC64;
MDVMNAFDSQ AEDSPTSLGR SLRRRPLARK KLSEMVEEEL EQMIRRHEFG EGEQLPSERE
LMAFFNVGRP SVREALAALK RKGLVQINNG ERARVSRPSA DTIISELSGM AKDFLTHPGG
IAHFEQLRLF FESSLVRYAA EHATDEQIAL LTKALEINSQ SLDDNALFIR SDVEFHRVLA
EIPGNPIFMA IHVALLDWLI AARPSVPDRE LHEHNNVSYQ QHIVIVDAIR QRDPDKADRA
LQTHLNSVSA TWHALGKKSQ KMR
