NANT2_ECOL6
ID NANT2_ECOL6 Reviewed; 502 AA.
AC Q8FDU9;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Sialic acid transporter NanT 2 {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid permease 2 {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid/H(+) symporter 2 {ECO:0000255|HAMAP-Rule:MF_01238};
GN Name=nanT2 {ECO:0000255|HAMAP-Rule:MF_01238}; OrderedLocusNames=c3637;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC {ECO:0000255|HAMAP-Rule:MF_01238}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
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DR EMBL; AE014075; AAN82085.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8FDU9; -.
DR STRING; 199310.c3637; -.
DR EnsemblBacteria; AAN82085; AAN82085; c3637.
DR KEGG; ecc:c3637; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_46_8_6; -.
DR OMA; CPSNARG; -.
DR BioCyc; ECOL199310:C3637-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01238; MFS_NanT; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004742; SA_transporter.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..502
FT /note="Sialic acid transporter NanT 2"
FT /id="PRO_0000050314"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
SQ SEQUENCE 502 AA; 55355 MW; 05416F367624DA1B CRC64;
MYYKSAIIVR FNMDSCIQKK QVWYKHLSPR QWKIFGAAWT GYLLDGFDFV LISLVLTEVQ
HEFGLTTIEA ASLISAAFIS RWFGGLAIGA LSDKMGRRMA MVLSIVLFSL GTLACGLAPG
YAVMFIARIV IGLGMAGEYG SSVTYVIESW PVHLRNKASG FLISGFSIGG GLAAQVYSIV
VPLWGWRSLF FVGMLPILFA FYLRKNLPES DDWQKRQQEN KPVRTMVDIL YREKNKYINI
LLSCIAFACL YVCFSGVTAN AALITVMALC CAAVFISFIY QGMGKRWPTG IMLMLVVMFC
FLYGWPLQAF LPTWLKVDMQ YSPETVALIF MLAGFGSAAG SCIGGFMGDW LGTRKAYVIS
LLIGQLVIIP VFLVDRDYVW LLGLLIFTQQ VFGQGIGALV PKIISGYFNV EQRAAGLGFI
YNVGSLGGAC APILGAVVAS HTSLGTAMCS LAFILTFVVL VLIGFDMPSR VQRWIHPEAA
LEYDTVDGKP FYGARKKNVA EE
