NANT_ESCF3
ID NANT_ESCF3 Reviewed; 496 AA.
AC B7LRJ2;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Sialic acid transporter NanT {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid permease {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid/H(+) symporter {ECO:0000255|HAMAP-Rule:MF_01238};
GN Name=nanT {ECO:0000255|HAMAP-Rule:MF_01238}; OrderedLocusNames=EFER_3195;
OS Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 / JCM
RC 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC {ECO:0000255|HAMAP-Rule:MF_01238}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
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DR EMBL; CU928158; CAQ90688.1; -; Genomic_DNA.
DR RefSeq; WP_000108485.1; NC_011740.1.
DR AlphaFoldDB; B7LRJ2; -.
DR EnsemblBacteria; CAQ90688; CAQ90688; EFER_3195.
DR KEGG; efe:EFER_3195; -.
DR HOGENOM; CLU_001265_46_8_6; -.
DR OMA; HWLLLTY; -.
DR OrthoDB; 1121832at2; -.
DR BioCyc; EFER585054:EFER_RS16095-MON; -.
DR Proteomes; UP000000745; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01238; MFS_NanT; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004742; SA_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00891; 2A0112; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..496
FT /note="Sialic acid transporter NanT"
FT /id="PRO_1000214054"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
SQ SEQUENCE 496 AA; 53639 MW; 5408BE5908F6B9E0 CRC64;
MSTTTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQGEF GLTTVQAASL
ISAAFISRWF GGLMLGAMGD RYGRRLAMVT SIVLFSVGTL ACGFAPGYIT MFIARLVIGM
GMAGEYGSSA TYVIESWPKH LRNKASGFLI SGFSVGAVVA AQVYSLVVPL WGWRALFFIG
ILPIIFALWL RKNIPEAEDW KEKHAGKAPV RTMVDILYRG EHRIANIVMT LAAATALWFC
FAGNLQNAAI VAVLGLLCAA IFISFMVQST GKRWPTGVML MVVVLFAFLY SWPIQALLPT
YLKTELAYNP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA SQLLIIPVFA
IGGANVWVLG LLLFFQQMLG QGISGILPKL IGGYFDTDQR AAGLGFTYNV GALGGALAPI
LGALIAQRLD LGTALGSLSF SLTFVVILLI GLDMPSRVQR WLRPEALRTH DAIDGKPFSG
AVPFGSAKND LVKTKS
