ID   NANT_SALAR              Reviewed;         496 AA.
AC   A9MNY7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Sialic acid transporter NanT {ECO:0000255|HAMAP-Rule:MF_01238};
DE   AltName: Full=Sialic acid permease {ECO:0000255|HAMAP-Rule:MF_01238};
DE   AltName: Full=Sialic acid/H(+) symporter {ECO:0000255|HAMAP-Rule:MF_01238};
GN   Name=nanT {ECO:0000255|HAMAP-Rule:MF_01238}; OrderedLocusNames=SARI_04286;
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC       {ECO:0000255|HAMAP-Rule:MF_01238}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC         acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01238}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC       symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01238}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000880; ABX24069.1; -; Genomic_DNA.
DR   RefSeq; WP_000108077.1; NC_010067.1.
DR   AlphaFoldDB; A9MNY7; -.
DR   STRING; 41514.SARI_04286; -.
DR   EnsemblBacteria; ABX24069; ABX24069; SARI_04286.
DR   KEGG; ses:SARI_04286; -.
DR   HOGENOM; CLU_001265_46_8_6; -.
DR   OMA; HWLLLTY; -.
DR   OrthoDB; 1121832at2; -.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01238; MFS_NanT; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004742; SA_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00891; 2A0112; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..496
FT                   /note="Sialic acid transporter NanT"
FT                   /id="PRO_1000214056"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
SQ   SEQUENCE   496 AA;  53823 MW;  21A5FB8F793D16F8 CRC64;
     MSTSTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQSEF GLTTVQAASL
     ISAAFISRWF GGLLLGAMGD RYGRRLAMVS SIILFSVGTL ACGFAPGYTT MFIARLVIGM
     GMAGEYGSSA TYVIESWPKH LRNKASGFLI SGFSVGAVVA AQVYSLVVPV WGWRALFFIG
     ILPIIFALWL RKNIPEAEDW KEKHEGKAPV RTMVDILYRG EHRIINILMT FAAAAALWFC
     FAGNLQNAAI VAALGLLCAV IFISFMVQSS GKRWPTGVML MLVVLFAFLY SWPIQALLPT
     YLKTELAYDP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA SQILIIPVFA
     IGGTNVWVLG LLLFFQQMLG QGIAGILPKL IGGYFDTDQR AAGLGFTYNV GALGGALAPI
     LGALIAQRLD LGTALASLSF SLTFVVILLI GLDMPSRVQR WLRPEALRTH DAIDDKPFSG
     AVPFGSSKDA FVKTKS