ID   NANT_SALPK              Reviewed;         496 AA.
AC   B5BGP4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Sialic acid transporter NanT {ECO:0000255|HAMAP-Rule:MF_01238};
DE   AltName: Full=Sialic acid permease {ECO:0000255|HAMAP-Rule:MF_01238};
DE   AltName: Full=Sialic acid/H(+) symporter {ECO:0000255|HAMAP-Rule:MF_01238};
GN   Name=nanT {ECO:0000255|HAMAP-Rule:MF_01238}; OrderedLocusNames=SSPA2993;
OS   Salmonella paratyphi A (strain AKU_12601).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=554290;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AKU_12601;
RX   PubMed=19159446; DOI=10.1186/1471-2164-10-36;
RA   Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A.,
RA   Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N.,
RA   Mungall K., Dougan G., Parkhill J.;
RT   "Pseudogene accumulation in the evolutionary histories of Salmonella
RT   enterica serovars Paratyphi A and Typhi.";
RL   BMC Genomics 10:36-36(2009).
CC   -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC       {ECO:0000255|HAMAP-Rule:MF_01238}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC         acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01238}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC       symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01238}.
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DR   EMBL; FM200053; CAR61242.1; -; Genomic_DNA.
DR   RefSeq; WP_000108076.1; NC_011147.1.
DR   AlphaFoldDB; B5BGP4; -.
DR   KEGG; sek:SSPA2993; -.
DR   HOGENOM; CLU_001265_46_8_6; -.
DR   OMA; HWLLLTY; -.
DR   Proteomes; UP000001869; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01238; MFS_NanT; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004742; SA_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00891; 2A0112; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..496
FT                   /note="Sialic acid transporter NanT"
FT                   /id="PRO_1000214066"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
SQ   SEQUENCE   496 AA;  53647 MW;  A0CE77CBF4D017ED CRC64;
     MSTSTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQSEF GLTTVQAASL
     ISAAFISRWF GGLLLGAMGD RYGRRLAMVS SIILFSVGTL ACGFAPGYTT MFIARLVIGM
     GMAGEYGSSA TYVIESWPKH LRNKASGFLI SGFSVGAVVA AQVYSLVVPV WGWRALFFIG
     ILPIIFALWL RKNIPEAEDW KEKHAGKAPV RTMVDILYRG EHRIINMLMT FAAAAALWFC
     FAGNLQNAAI VAGLGLLCAV IFISFMVQSS GKRWPTGVML MLVVLFAFLY SWPIQALLPT
     YLKTELAYDP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA SQILIIPVFA
     IGGTNVWVLG LLLFFQQMLG QGIAGILPKL IGGYFDTDQR AAGLGFTYNV GALGGALAPI
     LGALIAQRLD LGTALASLSF SLTFVVILLI GLDMPSRVQR WLRPEALRTH DAIDDKPFSG
     AVPLGSGKGA FVKTKS