NANT_SALTY
ID NANT_SALTY Reviewed; 496 AA.
AC P0A2G5; Q8XFJ3;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Sialic acid transporter NanT {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid permease {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid/H(+) symporter {ECO:0000255|HAMAP-Rule:MF_01238};
GN Name=nanT {ECO:0000255|HAMAP-Rule:MF_01238}; OrderedLocusNames=STM3338;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC {ECO:0000255|HAMAP-Rule:MF_01238}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
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DR EMBL; AE006468; AAL22207.1; -; Genomic_DNA.
DR RefSeq; NP_462248.1; NC_003197.2.
DR RefSeq; WP_000108071.1; NC_003197.2.
DR AlphaFoldDB; P0A2G5; -.
DR STRING; 99287.STM3338; -.
DR PaxDb; P0A2G5; -.
DR EnsemblBacteria; AAL22207; AAL22207; STM3338.
DR GeneID; 1254861; -.
DR KEGG; stm:STM3338; -.
DR PATRIC; fig|99287.12.peg.3539; -.
DR HOGENOM; CLU_001265_46_8_6; -.
DR OMA; HWLLLTY; -.
DR PhylomeDB; P0A2G5; -.
DR BioCyc; SENT99287:STM3338-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046943; F:carboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0046942; P:carboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01238; MFS_NanT; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004742; SA_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00891; 2A0112; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..496
FT /note="Sialic acid transporter NanT"
FT /id="PRO_0000050316"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
SQ SEQUENCE 496 AA; 53629 MW; A0CD5A4FF4D143A9 CRC64;
MSTSTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQSEF GLTTVQAASL
ISAAFISRWF GGLLLGAMGD RYGRRLAMVS SIILFSVGTL ACGFAPGYTT MFIARLVIGM
GMAGEYGSSA TYVIESWPKH LRNKASGFLI SGFSVGAVVA AQVYSLVVPV WGWRALFFIG
ILPIIFALWL RKNIPEAEDW KEKHAGKAPV RTMVDILYRG EHRIINILMT FAAAAALWFC
FAGNLQNAAI VAGLGLLCAV IFISFMVQSS GKRWPTGVML MLVVLFAFLY SWPIQALLPT
YLKTELAYDP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA SQILIIPVFA
IGGTNVWVLG LLLFFQQMLG QGIAGILPKL IGGYFDTDQR AAGLGFTYNV GALGGALAPI
LGALIAQRLD LGTALASLSF SLTFVVILLI GLDMPSRVQR WLRPEALRTH DAIDDKPFSG
AVPLGSGKGA FVKTKS
