ID   NANT_YERPA              Reviewed;         510 AA.
AC   Q1C5V2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Sialic acid transporter NanT {ECO:0000255|HAMAP-Rule:MF_01238};
DE   AltName: Full=Sialic acid permease {ECO:0000255|HAMAP-Rule:MF_01238};
DE   AltName: Full=Sialic acid/H(+) symporter {ECO:0000255|HAMAP-Rule:MF_01238};
GN   Name=nanT {ECO:0000255|HAMAP-Rule:MF_01238}; OrderedLocusNames=YPA_2205;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC       {ECO:0000255|HAMAP-Rule:MF_01238}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC         acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01238}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC       symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01238}.
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DR   EMBL; CP000308; ABG14170.1; -; Genomic_DNA.
DR   RefSeq; WP_002208513.1; NZ_CP009906.1.
DR   AlphaFoldDB; Q1C5V2; -.
DR   EnsemblBacteria; ABG14170; ABG14170; YPA_2205.
DR   KEGG; ypa:YPA_2205; -.
DR   OMA; HWLLLTY; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01238; MFS_NanT; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004742; SA_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..510
FT                   /note="Sialic acid transporter NanT"
FT                   /id="PRO_1000214071"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
SQ   SEQUENCE   510 AA;  55278 MW;  74AFC49DFDCE5507 CRC64;
     MSISVGPSRE DKPLSGGAKP PRWYKQLTPA QWKAFVAAWI GYALDGFDFV LITLVLTDIK
     QEFGLTLIQA TSLISAAFIS RWFGGLVLGA MGDRYGRKLA MITSIVLFSF GTLACGLAPG
     YTTLFIARLI IGIGMAGEYG SSSTYVMESW PKNMRNKASG FLISGFSIGA VLAAQAYSYV
     VLAFGWRMLF YIGLLPIIFA LWLRKNLPEA EDWEKAQSKQ KKGKQVTDRN MVDILYRSHL
     SYLNIGLTIF AAVSLYLCFT GMVSTLLVVV LGILCAAIFI YFMVQTSGDR WPTGVMLMVV
     VFCAFLYSWP IQALLPTYLK MDLGYDPHTV GNILFFSGFG AAVGCCVGGF LGDWLGTRKA
     YVTSLLISQL LIIPLFAIQG SSILFLGGLL FLQQMLGQGI AGLLPKLLGG YFDTEQRAAG
     LGFTYNVGAL GGALAPILGA SIAQHLSLGT ALGSLSFSLT FVVILLIGFD MPSRVQRWVR
     PSGLRMVDAI DGKPFSGAIT AQHARVVTQK