NANT_YERPE
ID NANT_YERPE Reviewed; 510 AA.
AC Q8ZCH3; Q0WCQ0;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Sialic acid transporter NanT {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid permease {ECO:0000255|HAMAP-Rule:MF_01238};
DE AltName: Full=Sialic acid/H(+) symporter {ECO:0000255|HAMAP-Rule:MF_01238};
GN Name=nanT {ECO:0000255|HAMAP-Rule:MF_01238};
GN OrderedLocusNames=YPO3016, y1465, YP_2640;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Catalyzes the proton-dependent transport of sialic acid.
CC {ECO:0000255|HAMAP-Rule:MF_01238}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-
CC acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:35418; Evidence={ECO:0000255|HAMAP-Rule:MF_01238};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01238}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sialate:H(+)
CC symporter (SHS) (TC 2.A.1.12) family. {ECO:0000255|HAMAP-
CC Rule:MF_01238}.
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DR EMBL; AL590842; CAL21619.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM85036.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62832.1; -; Genomic_DNA.
DR PIR; AH0366; AH0366.
DR RefSeq; WP_002208513.1; NZ_WUCM01000010.1.
DR RefSeq; YP_002347938.1; NC_003143.1.
DR AlphaFoldDB; Q8ZCH3; -.
DR IntAct; Q8ZCH3; 1.
DR STRING; 214092.YPO3016; -.
DR PaxDb; Q8ZCH3; -.
DR DNASU; 1146412; -.
DR EnsemblBacteria; AAM85036; AAM85036; y1465.
DR EnsemblBacteria; AAS62832; AAS62832; YP_2640.
DR KEGG; ype:YPO3016; -.
DR KEGG; ypk:y1465; -.
DR KEGG; ypm:YP_2640; -.
DR PATRIC; fig|214092.21.peg.3470; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_46_8_6; -.
DR OMA; HWLLLTY; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046943; F:carboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015538; F:sialic acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0046942; P:carboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01238; MFS_NanT; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004742; SA_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..510
FT /note="Sialic acid transporter NanT"
FT /id="PRO_0000050318"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01238"
FT CONFLICT 182
FT /note="L -> P (in Ref. 3; AAS62832)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 55278 MW; 74AFC49DFDCE5507 CRC64;
MSISVGPSRE DKPLSGGAKP PRWYKQLTPA QWKAFVAAWI GYALDGFDFV LITLVLTDIK
QEFGLTLIQA TSLISAAFIS RWFGGLVLGA MGDRYGRKLA MITSIVLFSF GTLACGLAPG
YTTLFIARLI IGIGMAGEYG SSSTYVMESW PKNMRNKASG FLISGFSIGA VLAAQAYSYV
VLAFGWRMLF YIGLLPIIFA LWLRKNLPEA EDWEKAQSKQ KKGKQVTDRN MVDILYRSHL
SYLNIGLTIF AAVSLYLCFT GMVSTLLVVV LGILCAAIFI YFMVQTSGDR WPTGVMLMVV
VFCAFLYSWP IQALLPTYLK MDLGYDPHTV GNILFFSGFG AAVGCCVGGF LGDWLGTRKA
YVTSLLISQL LIIPLFAIQG SSILFLGGLL FLQQMLGQGI AGLLPKLLGG YFDTEQRAAG
LGFTYNVGAL GGALAPILGA SIAQHLSLGT ALGSLSFSLT FVVILLIGFD MPSRVQRWVR
PSGLRMVDAI DGKPFSGAIT AQHARVVTQK
