ID   NAP2_SOLLC              Reviewed;         275 AA.
AC   K4BNG7;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=NAC domain-containing protein 2 {ECO:0000303|PubMed:29760199};
DE            Short=SlNAP2 {ECO:0000303|PubMed:29760199};
GN   Name=NAP2 {ECO:0000303|PubMed:29760199};
GN   OrderedLocusNames=Solyc04g005610.2.1 {ECO:0000305};
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Heinz 1706;
RX   PubMed=22660326; DOI=10.1038/nature11119;
RG   Tomato Genome Consortium;
RT   "The tomato genome sequence provides insights into fleshy fruit
RT   evolution.";
RL   Nature 485:635-641(2012).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY LEAF SENESCENCE AND ABSCISIC
RP   ACID, TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Moneymaker;
RX   PubMed=29760199; DOI=10.1104/pp.18.00292;
RA   Ma X., Zhang Y., Tureckova V., Xue G.-P., Fernie A.R., Mueller-Roeber B.,
RA   Balazadeh S.;
RT   "The NAC transcription factor SlNAP2 regulates leaf senescence and fruit
RT   yield in tomato.";
RL   Plant Physiol. 177:1286-1302(2018).
CC   -!- FUNCTION: Transcription factor that binds DNA motifs 5'-
CC       CGT[AG](5N)NACG[ACT][AC][AT][ACG][ACT]-3' and 5'-
CC       CACG[ACT][AC][AT][AGT][CT]-3' in target genes promoters. Promotes leaf
CC       senescence (developmental, light-induced and ABA-induced senescence)
CC       and regulates fruit yield and sugar content, probably by establishing
CC       abscisic acid (ABA) homeostasis. Activates the expression of senescence
CC       and ABA associated genes including NCED1, ABCG40, CYP707A2, SAG113,
CC       SGR1 and PAO, by directly binding to their promoters.
CC       {ECO:0000269|PubMed:29760199}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stem, flowers, and leaves.
CC       {ECO:0000269|PubMed:29760199}.
CC   -!- INDUCTION: Accumulates during age-dependent and dark-induced leaf
CC       senescence. Induced by abscisic acid (ABA).
CC       {ECO:0000269|PubMed:29760199}.
CC   -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC       domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC   -!- DISRUPTION PHENOTYPE: Delayed leaf senescence (including delayed leaf
CC       yellowing phenotype under darkness or after ABA treatment) but enhanced
CC       fruit yield and sugar content, likely due to prolonged leaf
CC       photosynthesis in aging plants; these phenotypes are increased in
CC       plants lacking both NAP1 and NAP2. {ECO:0000269|PubMed:29760199}.
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DR   EMBL; CM001067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004237044.1; XM_004236996.3.
DR   AlphaFoldDB; K4BNG7; -.
DR   SMR; K4BNG7; -.
DR   STRING; 4081.Solyc04g005610.2.1; -.
DR   PaxDb; K4BNG7; -.
DR   PRIDE; K4BNG7; -.
DR   EnsemblPlants; Solyc04g005610.3.1; Solyc04g005610.3.1; Solyc04g005610.3.
DR   GeneID; 101248665; -.
DR   Gramene; Solyc04g005610.3.1; Solyc04g005610.3.1; Solyc04g005610.3.
DR   KEGG; sly:101248665; -.
DR   eggNOG; ENOG502QSIY; Eukaryota.
DR   HOGENOM; CLU_035664_8_2_1; -.
DR   InParanoid; K4BNG7; -.
DR   OMA; NRQIGSM; -.
DR   OrthoDB; 1011164at2759; -.
DR   PhylomeDB; K4BNG7; -.
DR   Proteomes; UP000004994; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:1902265; P:abscisic acid homeostasis; IDA:UniProtKB.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0010150; P:leaf senescence; IDA:UniProtKB.
DR   GO; GO:0031155; P:regulation of reproductive fruiting body development; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0009737; P:response to abscisic acid; IMP:UniProtKB.
DR   GO; GO:0009646; P:response to absence of light; IMP:UniProtKB.
DR   Gene3D; 2.170.150.80; -; 1.
DR   InterPro; IPR003441; NAC-dom.
DR   InterPro; IPR036093; NAC_dom_sf.
DR   Pfam; PF02365; NAM; 1.
DR   SUPFAM; SSF101941; SSF101941; 1.
DR   PROSITE; PS51005; NAC; 1.
PE   2: Evidence at transcript level;
KW   Abscisic acid signaling pathway; Activator; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..275
FT                   /note="NAC domain-containing protein 2"
FT                   /id="PRO_0000445684"
FT   DOMAIN          10..162
FT                   /note="NAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT   DNA_BIND        107..168
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ   SEQUENCE   275 AA;  31877 MW;  733EA5E74AC2A0E1 CRC64;
     MVGKNNSNHL PPGFRFHPTD EELIMYYLRN QATSKPCPSS IIPEVDVYKF DPWELPEKTE
     FGEKEWYFFT PRDRKYPNGV RPNRAAVSGY WKATGTDKGI YSGTKYVGIK KALVFYKGKP
     PKGIKTDWIM HEYRLSESRT QPTRPNGSMR LDDWVLCRIY KKKNLERAIE MMKVEEDTQE
     PQIMSVTNPI HEVVASNGQQ TLKLPRTCSL SHLLEMDYFG SISQLFDDNN SYNTISQNNT
     LMTNVNGYVM PHQAMEKFQL GEVSQISMNP SYQFQ