ID   NAPA_NEMVE              Reviewed;        1120 AA.
AC   A7RU46;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Nck-associated protein 1 homolog;
GN   Name=napA; ORFNames=v1g182004;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC       Involved in cell adhesion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a Scar/WAVE complex containing brk1, scrA, abiA, pirA
CC       and napA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEM-1/HEM-2 family. {ECO:0000305}.
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DR   EMBL; DS469539; EDO45022.1; -; Genomic_DNA.
DR   RefSeq; XP_001637085.1; XM_001637035.1.
DR   AlphaFoldDB; A7RU46; -.
DR   SMR; A7RU46; -.
DR   STRING; 45351.EDO45022; -.
DR   EnsemblMetazoa; EDO45022; EDO45022; NEMVEDRAFT_v1g182004.
DR   GeneID; 5517043; -.
DR   KEGG; nve:5517043; -.
DR   eggNOG; KOG1917; Eukaryota.
DR   HOGENOM; CLU_004450_0_0_1; -.
DR   InParanoid; A7RU46; -.
DR   OMA; VGMVMYN; -.
DR   OrthoDB; 138196at2759; -.
DR   PhylomeDB; A7RU46; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0031209; C:SCAR complex; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR   GO; GO:0030031; P:cell projection assembly; IBA:GO_Central.
DR   GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   InterPro; IPR019137; Nck-associated_protein-1.
DR   PANTHER; PTHR12093; PTHR12093; 1.
DR   Pfam; PF09735; Nckap1; 1.
PE   3: Inferred from homology;
KW   Cell adhesion; Reference proteome.
FT   CHAIN           1..1120
FT                   /note="Nck-associated protein 1 homolog"
FT                   /id="PRO_0000331390"
SQ   SEQUENCE   1120 AA;  128390 MW;  CFCB7E96DFD399AF CRC64;
     MERGLSVTEQ KLAEKLTILN ERGEGMLTRI YNIKKACSDP KSRPGFLMDK ALEPSIKYIV
     RKFPQMDTKA TQLQAVQSIQ NEVMKGLSNY YFTFVDIMEF KDNASELLTA IDASFVHFDI
     TLNFDLTKAY LDLIVTLTAL MIMVSRVDDR RSVLGLFNHA FEMRNGRSEE SFPRLGQMIL
     DYDSPLKKLA EQFVPHQQRV STALQSLHEI YLRKSMTGEQ WRQGQILSII NAPANILVPG
     QSKVPAVEYL EVSVIQRWIM FGYTMCHQQL AMPGITDIWK MALQDGFCIT LFRDEIFMFH
     KEFHNMLDGM KGYGKRIKDI QDAANQMAAS VGIHKERRNY LRSALTEMTL ILADQPGLLG
     PKMLIILHGL SIAHDEILWL VRHCCNPAPR SRKLTQEDFF DSKLPHLLFA VEELRSMVQK
     YSSVLQRYFI QYLSGFDVYM LKQVVQKISI CSEDISLIMT SFIDELSSLS VKQVESGELF
     HFSGLRLDWL RLQAYTSVRG SSPELKDNRD LVELMNNVVF HSKLVDLQDE TLAEVSDLSI
     FCFYPGFFEE SFVRCLEDIT QSRYCIAFPL ICGHFMTCTS DFCPEERHPI GDRSLSAVNL
     FLDSMAKEAR NIMSQVCSEH IQQHQQLWHT HAVRMMTEMA SERRTKDKNK KNVHVEFKPP
     GIESFRKSRE TLTSLDTKLL SLTELCHAIT HTEAIPVWEH IFAPKEYLSS QLEEFFAKAV
     VSMAQYDIDN QRIARPSEVL SNVKAMMSSL RSLENYTGVD TARVFNHVLL QQTQPQDSQG
     ANTITQMYTT WYLDVFLRRV MTDGIVYSPR RMAFVNRPGM PFRAEEYTDV NELQALAELL
     GAYGMRYLGE KMMLQIASQV SELKKLVIMN KDVLVALRTN FDKPEQCIEL IRRLRNMDDV
     MLRMIIIGVI LSFRQLIQQA LDSVLKTRVP YMMSCITDMR KNFPHGNNDR QVVDEMATSA
     GQECVVDPLL CAALRTLKEK KSEDDILTWS LLLVFVAVGL PSLAYKDASE YNGELEAHDN
     NAHCISSSVN SITGALCSNN GDNPEDRLRE FLAITSSSLL KLGMEAEKDL KARESVYLLL
     DMVVQQSPYL TMDVLESCFP YALLRNAYHE VYQKRKEPFL