NAR1_ASPFU
ID NAR1_ASPFU Reviewed; 597 AA.
AC Q4WQ87;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Cytosolic Fe-S cluster assembly factor nar1;
DE AltName: Full=Nuclear architecture-related protein 1;
GN Name=nar1; ORFNames=AFUA_4G11960;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC Required for maturation of extramitochondrial Fe/S proteins. May play a
CC role in the transfer of pre-assembled Fe/S clusters to target
CC apoproteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; AAHF01000005; EAL89597.1; -; Genomic_DNA.
DR RefSeq; XP_751635.1; XM_746542.1.
DR AlphaFoldDB; Q4WQ87; -.
DR SMR; Q4WQ87; -.
DR STRING; 746128.CADAFUBP00006715; -.
DR EnsemblFungi; EAL89597; EAL89597; AFUA_4G11960.
DR GeneID; 3509141; -.
DR KEGG; afm:AFUA_4G11960; -.
DR VEuPathDB; FungiDB:Afu4g11960; -.
DR eggNOG; KOG2439; Eukaryota.
DR HOGENOM; CLU_018240_0_1_1; -.
DR InParanoid; Q4WQ87; -.
DR OMA; PHEQRAW; -.
DR OrthoDB; 705416at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..597
FT /note="Cytosolic Fe-S cluster assembly factor nar1"
FT /id="PRO_0000383716"
FT REGION 25..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 20
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 61
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 64
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 67
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 208
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 263
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 464
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 468
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64361 MW; 22ED1664E70A8D3E CRC64;
MSAILSADDL NDFISPGVAC IKPVESLPQK ESQSENPYEV TKEDKVQPEN LPPAQISLTD
CLACSGCVTS AEAVLISLQS HTEVLNTLDS YPELPLGSTS YQRGTQKVGS ADSDGRIFVA
SVSPQVRASL AATYGITERE AKYMIDQFLM GPHGLRAGGK HGNGFTWVVD TNVMREAVLA
LTADEVTSSL LSTGSGSLPK SPILSSACPG WICYAEKTHP FILPHLSRLK SPQALSGTFL
KSVLSKALGV PPSQIWHLAI MPCFDKKLEA SREELTDIAW ASTFTQSQTT PVRDVDCVIT
TRELLTLATA RGLSLPNLPL KPLPASCLTP FPDQALESFL FSKSSSGQTV ESGTSGGYLH
HVLQIFQARN PGSKIVTQRG RNADVVEYVL MSSGDEPLFR AARYYGFRNI QNLVRKLKPA
RVSRLPGAKP QAVSSSANRR QPMSRNAAPA GTGADYAYVE VMACPGGCTN GGGQIRIEDA
REAVPNALKE TSTETPVAAP KPTPHEQRAW LARVDEAYYS ADSDSEGSVT TEPVSVLSRD
NQIHEFLNYW SEKVDIPLSR LAYTSYREVE SDVGKTKNAP NETARVVELA GKIGGGW
