NAR1_ASPNC
ID NAR1_ASPNC Reviewed; 597 AA.
AC A2Q9A9;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Cytosolic Fe-S cluster assembly factor nar1;
DE AltName: Full=Nuclear architecture-related protein 1;
GN Name=nar1; ORFNames=An01g07240;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC Required for maturation of extramitochondrial Fe/S proteins. May play a
CC role in the transfer of pre-assembled Fe/S clusters to target
CC apoproteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; AM269972; CAK43843.1; -; Genomic_DNA.
DR RefSeq; XP_001389148.1; XM_001389111.1.
DR AlphaFoldDB; A2Q9A9; -.
DR PaxDb; A2Q9A9; -.
DR EnsemblFungi; CAK43843; CAK43843; An01g07240.
DR GeneID; 4978195; -.
DR KEGG; ang:ANI_1_960014; -.
DR VEuPathDB; FungiDB:An01g07240; -.
DR HOGENOM; CLU_018240_0_1_1; -.
DR Proteomes; UP000006706; Chromosome 2R.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..597
FT /note="Cytosolic Fe-S cluster assembly factor nar1"
FT /id="PRO_0000383717"
FT REGION 428..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 20
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 62
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 65
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 68
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 216
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 271
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 462
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 466
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64000 MW; 10A669F11DEDEDE3 CRC64;
MSAILSADDL NDFISPGVAC IKPVETLPAK DPSKTDNPYE VTTEDKVQPE NLPPAQISLT
DCLACSGCVT SAEAVLISLQ SHAEVLNTLD AHPELPLNRE DGTITQELGT ASDEGRVFVA
SVSPQVRASL AATYGITEKE ATYMIHQFLS GPHGLRAGGK NGSGFTWVAD TNVLREAVLV
LTADEVGETL TTSPDSPSTN GATNTLPKRP ILSSACPGWI CYAEKTHPFV LPHLSRLKSP
QALAGTFFKT VLSKSLGIPA SRIWHLAVMP CFDKKLEASR EELTDASWLS AKDEDHTAVR
DVDCVITTRE MLSLASSRGI SLPNLPLKSL PQSYIPPFPD MTLNDFLFSK SSPGQSAAAG
TSGGYLHHVL QTFQARNPGS EIVTQRGRNA DVVEYTLMSS EHTPILKAAR YYGFRNIQNL
VRKLKPARAS RLPGGNRRLP VGRGAASGSS GTDYAYVEVM ACPGGCTNGG GQIRIEDARE
ASSSVQSSTS AEVPDSSSKP TPHEQRAWLA RVDEAYYSAE SDTESEAGSQ SQPLSILDKE
DKIHNAMRYW SDSMGIPLSK LAYTTYREVE SDVGKSQPAA TDTTRVAELA GKIGGGW
