NAR1_ASPOR
ID NAR1_ASPOR Reviewed; 607 AA.
AC Q2UJY8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Cytosolic Fe-S cluster assembly factor nar1;
DE AltName: Full=Nuclear architecture-related protein 1;
GN Name=nar1; ORFNames=AO090003001020;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC Required for maturation of extramitochondrial Fe/S proteins. May play a
CC role in the transfer of pre-assembled Fe/S clusters to target
CC apoproteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; AP007155; BAE58127.1; -; Genomic_DNA.
DR RefSeq; XP_001820129.1; XM_001820077.2.
DR AlphaFoldDB; Q2UJY8; -.
DR STRING; 510516.Q2UJY8; -.
DR EnsemblFungi; BAE58127; BAE58127; AO090003001020.
DR GeneID; 5992112; -.
DR KEGG; aor:AO090003001020; -.
DR VEuPathDB; FungiDB:AO090003001020; -.
DR HOGENOM; CLU_018240_0_1_1; -.
DR OMA; PHEQRAW; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..607
FT /note="Cytosolic Fe-S cluster assembly factor nar1"
FT /id="PRO_0000383718"
FT REGION 28..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 20
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 62
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 65
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 68
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 214
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 269
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 475
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 479
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 607 AA; 65494 MW; 590E1D0F6953BC61 CRC64;
MSAILSADDL NDFISPGVAC IKPVETLPKN ESSNSQNPYE VTTEDKVQPE NLPPAQISLT
DCLACSGCVT SAEAVLISLQ SHAEVLNTLD AYPELPLTQN HNGPYTGSSD ALDGESRIFV
ASVSPQVRAS LAATYGISEK EATYMIDQFL SGPHGLRAGG KHGSGFSWVV DTNVMRDAIL
VLTADEVSET LKEPSARAIS KDTLPKRPVL SSACPGWICY AEKTHPFVLP HLSRLKSPQA
LTGTFLKTVL SKALGVPPSR VWHLAIMPCF DKKLEASREE LTDVSWSPLD GGVPLTESNK
PVRDVDCVIT TRELLTLASS RGISLPTLPL KSLAPSYTPH FPDETLNAFL FRKQNGSEQS
MEAGTSGGYL HHVLKTFQAK NPGSEIVTQR GRNADVVEYS LMSPGGEPLM KAARYYGFRN
IQNLVRKLKP ARVSRLPGAR VPAASAGGNR RQPISRNSAS AGSGTDFAYV EVMACPGGCT
NGGGQIRIED AREASTSTQS VTAVENPSKP TPHEQRAWLA RVDEAYFSAE SDAEGEMDGQ
AQPLTIPERE ARVHEAFEYW SNLMNIPLSK LVYTTYREVE SDVGKPKDAP IDTTRVVELA
GKIGGGW
