NAR1_CANAL
ID NAR1_CANAL Reviewed; 607 AA.
AC Q5APK7; A0A1D8PEJ3;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Cytosolic Fe-S cluster assembly factor NAR1;
DE AltName: Full=Nuclear architecture-related protein 1;
GN Name=NAR1; OrderedLocusNames=CAALFM_C109010WA;
GN ORFNames=CaO19.12221, CaO19.4757;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC Required for maturation of extramitochondrial Fe/S proteins. May play a
CC role in the transfer of pre-assembled Fe/S clusters to target
CC apoproteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26536.1; -; Genomic_DNA.
DR RefSeq; XP_723443.2; XM_718350.2.
DR AlphaFoldDB; Q5APK7; -.
DR SMR; Q5APK7; -.
DR STRING; 237561.Q5APK7; -.
DR PRIDE; Q5APK7; -.
DR GeneID; 3634916; -.
DR KEGG; cal:CAALFM_C109010WA; -.
DR CGD; CAL0000185143; NAR1.
DR VEuPathDB; FungiDB:C1_09010W_A; -.
DR eggNOG; KOG2439; Eukaryota.
DR HOGENOM; CLU_018240_0_1_1; -.
DR InParanoid; Q5APK7; -.
DR OrthoDB; 705416at2759; -.
DR PRO; PR:Q5APK7; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..607
FT /note="Cytosolic Fe-S cluster assembly factor NAR1"
FT /id="PRO_0000383721"
FT REGION 430..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 20
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 82
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 85
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 88
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 204
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 259
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 496
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 500
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 607 AA; 67085 MW; 1532950F0CBA38EA CRC64;
MSALLSADDL NDFISPGVAC IKPLASSSTN TTTTNTTDSY NENGEVEIQI DSQGNPLEIS
KIDDKQFQTN KLTPAQISLA DCLACSGCIT SAEEVLVAQH SHQELIKALQ SQKETNKVFV
VSISHQSRAS LAMAYNVSIE NMDKCLIDLF IRQMGFTYIV GTSLGRKLSL INEAKEIINR
KTKGSGTGGI DSDSSSGPIL SSICPGWVLY AEKTHPYIIP KMSTVKSPQQ ITGCLLKNLT
SNSLNIEKSK IYHLSIMPCF DKKLESARPE VYEEEEEEEE EKDKALVSVP DVDCVITAKE
LITLLEECPQ YQLIPPTLPQ EELIGGGCLS MTEIYKQYAP PNWPFIEISW SNDSGSASGG
YAYNYLTIYR NDLILKGYDG NKFTINLING RNPDIYEMRL MYNGENKEKL ASAAVVNGFR
NIQNLVRKLK PNTGKSTNTT TTTTKSKVNP LAARRRARIA NNRGKPETKS TSEVNSQEME
IVADASKVDY VEIMACPNGC INGGGQISAP NTTTTSITLP QKEIEKQWIN AVLEKYNSIP
MFDLSSQSSS SSSPNEIIKF IEWSKKFENQ FNISDNRLFK THFNPVEKNI IMSVDDPATA
LLVGSKW
