ID   NAR1_CANDC              Reviewed;         584 AA.
AC   B9W8S4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Cytosolic Fe-S cluster assembly factor NAR1;
DE   AltName: Full=Nuclear architecture-related protein 1;
GN   Name=NAR1; ORFNames=CD36_08500;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC       Required for maturation of extramitochondrial Fe/S proteins. May play a
CC       role in the transfer of pre-assembled Fe/S clusters to target
CC       apoproteins (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; FM992688; CAX45147.1; -; Genomic_DNA.
DR   RefSeq; XP_002417494.1; XM_002417449.1.
DR   AlphaFoldDB; B9W8S4; -.
DR   SMR; B9W8S4; -.
DR   STRING; 42374.XP_002417494.1; -.
DR   EnsemblFungi; CAX45147; CAX45147; CD36_08500.
DR   GeneID; 8045039; -.
DR   KEGG; cdu:CD36_08500; -.
DR   CGD; CAL0000166245; Cd36_08500.
DR   VEuPathDB; FungiDB:CD36_08500; -.
DR   eggNOG; KOG2439; Eukaryota.
DR   HOGENOM; CLU_018240_0_1_1; -.
DR   OrthoDB; 705416at2759; -.
DR   Proteomes; UP000002605; Chromosome 1.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding.
FT   CHAIN           1..584
FT                   /note="Cytosolic Fe-S cluster assembly factor NAR1"
FT                   /id="PRO_0000383722"
FT   BINDING         20
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         81
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         84
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         87
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         190
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         245
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         465
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         469
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   584 AA;  65021 MW;  CE943CAC29EE1AFE CRC64;
     MSALLSADDL NDFISPGVAC IKPPASTNTN TNTTTTDSYN ENGEVEIQID SQGNPLEISK
     IDGKQIQTNQ LTPAQISLAD CLACSGCITS AEEVLVAQHS HQELIKALQS PTKNKVFVVS
     ISHQSRASLA MAYNVTIEIM DKLLINLFIK QMGFTYIIGT SLGRKLSLIN EAKEVINRKT
     EEGPILSSIC PGWVLYAEKT HPYIIPKLST IKSPQQITGC LLKNLTCEAL QIDKSEIYHL
     SIMPCFDKKL ESARPEIYDN ENEEDKSISI SVPDVDCVIT AKELITLLEE CPQYQLIPPQ
     PTQPTLGGDL DLSVTEIYKQ YAPPNWPFIE YSWSNDSGSS SGGYAYNYLN IYRNDLVLRK
     GYDPNKFTIN LINGRNSDIY EMRLIYDSKE TLASAAVVNG FRNIQNLVRK LKPNTNKSMN
     NKINPLVARR RARMINRGKS ESISQEIEIE IADASKVDYV EIMACPNGCI NGGGQINPPT
     TTTISNTTGL PQKEIEKQWI NKVLDKYNTI PILFDLSLPS TSSSLEIMKY IEWSENFEKH
     FNISNDRLFK ISFNPRENKS TGTATTTDDN NDPAATALLV GSKW